Peptide Aptamers
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p21 ▶Ras
PABP ▶Poly(A)-Binding Protein
PABPN1 P300/CBP ▶Nuclear Poly(A) Binding Protein 1
Definition Related proteins p300 and CBP (cAMP-responseelement-binding protein (CREB)- binding protein)) are transcriptional co-activators that act with other factors to regulate gene expression, and play roles in many pathways involved in cell-differentiation and signal transduction. ▶Catalytic RNA
p53 Definition P53 is a phosphoprotein and transcription factor encoded by the p53 gene, which acts as a powerful tumor suppressor gene, and is mutated in many cancer cells or tumors. It plays a critical role as a sensor for a variety of stress signals, triggering protective responses such as cell-cycle arrest, apoptosis, and DNA repair. Mutations or chromosomal deletions of the p53 locus are associated with a poor prognosis in chronic B-cell lymphocytic leukaemia (B-CLL). ▶Jun/Fos ▶Leukemia ▶RNA Polymerase III ▶Senescence ▶Tumor Suppressor Genes
PAC Definition Phage artificial chromosomes are large, extrachromosomal DNA constructs (see also ▶BAC, ▶YAC). Artificial chromosomes have become important tools allowing the establishment of comprehensive genomic libraries, and also has potential as gene delivery vectors for gene therapy. ▶Hereditary Neuropathies, Motor and/or Sensor
PAC Transgene ▶YAC/PAC/BAC Transgene
Pacemaker Definition The mammalian CNS contains a biological clock that drives remarkably precise circadian rhythms. An
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Pachyonychia Congenita
ensemble of coupled neurons in the suprachiasmatic nucleus (SCN) of the hypothalamus comprises of the principal circadian pacemaker, which is capable of both sustaining its own oscillation (daily light/dark cycle) and of synchronizing signals to local circadian oscillators in peripheral tissues. ▶Circadian Clocks
Pachyonychia Congenita
2D-PAGE Database Definition These databases present 2–dimensional electrophoresis patterns in the www. Clicking on spots gives the user the identity of the protein species and further information such as Mr (relative molecular mass), isoelectric point, and links to genome, protein sequence, pathway and other databases. In more developed 2D–PAGE databases, mass spectrometry data and functional data allows the mining of proteomics data. ▶Two-Dimensional Gel Electrophoresis
Definition Pachyonychia congenita is an autosomal dominant inherited disorder caused by mutations in keratin genes, contributing to structural stability of cells of the outer root sheath of the hair follicle. Hallmark of the disease is thickened nails. However, additional variable involvement of hair, sebaceous glands and oral mucosa can occur, depending on which keratin gene is mutated (e.g. palmoplantar keratoderma and oral leukoplakia in K6a, K16 mutants, versus pilosebaceous cysts, twisted hairs and natal teeth in K6b or K17 mutants). ▶Heritable Skin Disorders ▶Intermediate Filaments
Paclitaxel
Paget’s Disease Definition Paget’s disease is a generalized skeletal chronicprogressive disease – often familial – in which bone turnover is increased, leading to thicke
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