Dedifferentiated chondrosarcoma with leukocytosis and elevation of serum G-CSF. A case report
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Case report
Dedifferentiated chondrosarcoma with leukocytosis and elevation of serum G-CSF. A case report Akio Sakamoto*1, Hidetaka Yamamoto2, Kazuhiro Tanaka1, Shuichi Matsuda1, Katsumi Harimaya1, Yoshinao Oda2, Masazumi Tsuneyoshi2 and Yukihide Iwamoto1 Address: 1Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, 812-8582, Japan and 2Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, 812-8582, Japan Email: Akio Sakamoto* - [email protected]; Hidetaka Yamamoto - [email protected]; Kazuhiro Tanaka - [email protected]; Shuichi Matsuda - [email protected]; Katsumi Harimaya - [email protected]; Yoshinao Oda - [email protected]; Masazumi Tsuneyoshi - [email protected]; Yukihide Iwamoto - [email protected] * Corresponding author
Published: 04 July 2006 World Journal of Surgical Oncology 2006, 4:37
doi:10.1186/1477-7819-4-37
Received: 19 February 2006 Accepted: 04 July 2006
This article is available from: http://www.wjso.com/content/4/1/37 © 2006 Sakamoto et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract Background: G-CSF is known to function as a hematopoietic growth factor and it is known to be responsible for leukocytosis. G-CSF-producing tumors associated with leukocytosis include various types of malignancies. Case presentation: We report the case of a 72-year-old man with dedifferentiated chondrosarcoma characterized by dedifferentiated components of malignant fibrous histiocytomaor osteosarcoma-like features in addition to conventional chondrosarcoma, arising from his pelvic bone. After hemipelvectomy, when local recurrence and metastasis were identified, leukocytosis appeared and an elevated level of serum granulocyte-colony-stimulating factor (G-CSF) was also recognized. The patient died of multiple organ failure 2 months after surgery. Autopsy specimens showed that the histological specimens of the recurrence and metastasis were dedifferentiated components, without any conventional chondrosarcoma components. G-CSF was expressed only in the dedifferentiated components, not in the chondrosarcoma components, immunohistochemically. Conclusion: This is the first report of chondrosarcoma, or any other primary bone tumor, with leukocytosis, probably stimulated by tumor-produced G-CSF from the dedifferentiated components.
Background Granulocyte-colony stimulating factor (G-CSF) enhances differentiation along the neutrophil lineage, and accelerates maturation of metamyelocytes into mature neutrophils. G-CSF also prolongs the survival of neutrophils
and their precursors, including stem cells[1]. Consequently, G-CSF is known to
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