Delayed-type Hypersensitivity to Metals in Newly Diagnosed Patients with Nonischemic Dilated Cardiomyopathy
- PDF / 899,740 Bytes
- 10 Pages / 595.276 x 790.866 pts Page_size
- 98 Downloads / 162 Views
Delayed‑type Hypersensitivity to Metals in Newly Diagnosed Patients with Nonischemic Dilated Cardiomyopathy Jan Manousek1 · Marian Felsoci1 · Roman Miklik2 · Jiri Parenica1 · Jan Krejci3 · Geir Bjørklund4 · Jana Klanova5 · Dalibor Mlejnek3 · Marie Miklikova1 · Petr Lokaj1 · Salvatore Chirumbolo6,7 · Jindrich Spinar1
© Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract The causes of nonischemic dilated cardiomyopathy are classified as genetic or nongenetic, but environmental factors such as metal pollutants may interact with genetic susceptibility. The presence of metal particles has been detected in the myocardium, including in those patients with dilated cardiomyopathy. It is also known that hypersensitivity reactions can induce inflammation in tissue. The present study aimed to verify if metal-induced delayed-type hypersensitivity is present in patients with nonischemic dilated cardiomyopathy. The patient group consisted of 30 patients with newly diagnosed dilated cardiomyopathy; the control group comprised 41 healthy subjects. All patients and control subjects provided blood samples for lymphocyte transformation testing (MELISA®) to assess possible hypersensitivity to seven common metals. Specific exposure to metals was based on interview data. Results showed that exposure to cadmium and lead (p = 0.0002), aluminum (p = 0.0006), nickel (p = 0.0012), and chromium (p = 0.0065) was more often reported by patients than controls. The patients also had significantly more frequent hypersensitivity reactions to mercury (26.7% vs. 7.3%, p = 0.014624), nickel (40% vs. 12.2%, p = 0.02341), and silver (20% vs. 4.8%, p = 0.025468) than the control group. Patients with dilated cardiomyopathy had greater exposure to certain metals compared with healthy controls. Hypersensitivity to metals was more frequent in patients with dilated cardiomyopathy, suggesting a possible association that warrants further investigation. Keywords Dilated cardiomyopathy · Metal exposure · Delayed-type hypersensitivity · Lymphocyte transformation test · Inflammation
Introduction Nonischemic dilated cardiomyopathy, which is a major cause of heart failure, is a clinical diagnosis characterized by dilatation and impaired contraction of the left or both Handling Editor Travis Knuckles . * Roman Miklik [email protected]
4
Council for Nutritional and Environmental Medicine (CONEM), Toften 24, 8610 Mo i Rana, Norway
* Geir Bjørklund [email protected]
5
Research Centre for Toxic Compounds in the Environment (RECETOX), Faculty of Science, Masaryk University, Brno, Czech Republic
6
Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy
7
CONEM Scientific Secretary, Verona, Italy
1
Department of Internal Medicine and Cardiology, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czech Republic
2
Department of Cardiology, University Hospital and Faculty of Medicine Pilsen, Charles University, Prague, Czech Republic
3
Department of Cardiova
Data Loading...
