Determinants of placental iodine concentrations in a mild-to-moderate iodine-deficient population: an ENVIR ON AGE cohor
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Journal of Translational Medicine Open Access
RESEARCH
Determinants of placental iodine concentrations in a mild‑to‑moderate iodine‑deficient population: an ENVIRONAGE cohort study Kristof Y. Neven1* , Bianca Cox1, Karen Vrijens1, Michelle Plusquin1, Harry A. Roels1,2, Ann Ruttens3 and Tim S. Nawrot1,4
Abstract Background: Iodine is an essential trace element for the production of thyroid hormones, and plays a key role during the gestational period for optimal foetal growth and (neuro-)development. To this day, iodine deficiency remains a global burden. Previous studies indicate that the placenta can store iodine in a concentration-dependent manner and serve as a long-term storage supply, but studies on the determinants of long-term placental iodine load are limited. Methods: The placental iodine concentrations were determined for 462 mother-neonate pairs from the ENVIRONAGE birth cohort (Limburg, Belgium). Sociodemographic and clinical variables were obtained from questionnaires and medical files. Determinants of placental iodine concentration were identified using stepwise multiple regression procedures (p value
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