Development of Function in the Fetus

The mesonephros is the functional adult kidney in amphibia and fish and is an essential precursor for the formation of the metanephros. Thus, gene defects which prevent formation of a mesonephros inevitably result in total anephric neonates. The transient

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Anatomy Embryology and Cell Biology

Editors F.F. Beck, Melbourne . F. Clascá, Madrid M. Frotscher, Freiburg . D.E. Haines, Jackson N. Hirokawa, Tokyo . Z. Kmiec, Gdansk H.-W. Korf, Frankfurt . E. Marani, Enschede R. Putz, München . Y. Sano, Kyoto T.H. Schiebler, Würzburg J.-P. Timmermans, Antwerpen

K.M. Moritz, E.M. Wintour, M.J. Black, J.F. Bertram and G. Caruana

Factors Influencing Mammalian Kidney Development: Implications for Health in Adult Life With 12 Figures

Karen M. Moritz School of Biomedical Sciences, University of Queensland, St Lucia 4072 Australia e-mail: [email protected] M. Jane Black John F. Bertram Georgina Caruana Department of Anatomy and Cell Biology, Monash University, Clayton, Victoria 3800 Australia Marelyn Wintour-Coghlan Department of Physiology, Monash University, Clayton, Victoria 3800 Australia e-mail: [email protected]

ISSN 0301-5556 ISBN 978-3-540-77767-0

e-ISBN 978-3-540-77768-7

Library of Congress Control Number: 2008923172 © 2008 Springer-Verlag Berlin Heidelberg This work is subject to copyright. All rights are reserved, whether the whold or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting reporduction on microfilm or in any other way, and storage in data banks. Duplication of this publication or parts thereof is permitted only under the provisions of the German Copyright Law of September 9, 1965, in its current version, and permission for use must always be obtained from Springer-Verlag. Violations are liable to prosecution under the German Copyright Law. The use of general descriptive names, registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt form the relevant protecttive laws and regulations and therefore free for general use. Product liability: The publishers cannot guarantee the accuracy of any information about dosage and application contained in this book. In every individual case the user must check such information by consulting the relevant literature. Printed on acid-free paper 9 8 7 6 5 4 3 2 1 springer.com

List of Contents

1

Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

1

2 2.1 2.2 2.3 2.4 2.5

Morphological Development of the Mammalian Kidney . . . . . . . . . . . . . . . . . . . Pronephros . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Mesonephros . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Metanephros . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Renal Vascular Development . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Development of the Renal Nerves. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

1 3 3 5 7 9

3 3.1 3.2

9 10 1