Development of topical natural based film forming system loaded propolis from stingless bees for wound healing applicati
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Journal of Pharmaceutical Investigation https://doi.org/10.1007/s40005-020-00493-w
ORIGINAL ARTICLE
Development of topical natural based film forming system loaded propolis from stingless bees for wound healing application Kampanart Huanbutta1 · Wancheng Sittikijyothin2 · Tanikan Sangnim1 Received: 4 February 2020 / Accepted: 20 June 2020 © The Korean Society of Pharmaceutical Sciences and Technology 2020
Abstract Purpose Propolis extract is an extraction of a resinous mixture of honey bees produced by mixing saliva and beeswax with exudate gathered from tree. The prominent pharmacological activities of propolis extract are antioxidant, antimicrobial, fungicidal, antiviral, antiulcer, immune-stimulating, and cytostatic, which are very suitable for topical formulation. Methods From its various pharmacological activities, propolis extract was formulated in film forming system using modified tamarind seed gum as a solution/gel/film forming agent. To obtain the optimum seed gum concentration of the film forming system (solution to film), various tamarind concentrations and solvent ratios were evaluated. Results The formulation of 7.5% of modified tamarind seed gum with 1% PEG400 dissolved in 55%:45% of water:ethanol provided fast drying time (4.36 min) and proper rheological property for spaying application. The propolis extract loaded formulation could inhibit Staphylococcus aureus and Staphylococcus epidermidis. Moreover, the product satisfaction evaluation was excellent (3.8 from 5). Conclusion The results indicate the possibility of introducing modified tamarind seed gum and propolis extract as a component in the development of film forming systems and increasing the effectiveness of antibacterial on the skin. Keywords Film forming system · Propolis · Gum · Tamarind seed · Stingless bee
Introduction For more than four decades, researchers have tried to develop pharmaceutical formulations administered through the skin for topical treatment of skin diseases or transdermal absorption of drugs to the systemic circulation (Touitou 2002). However, the current topical pharmaceutical dosage forms, including, ointments, creams, patches, solution, and gel, are still associated with many limitations. For example, semisolid preparations such as creams and ointment are not in persistent contact with the skin surface and can be easily wiped off by clothes or contact. Consequently, these formulations require frequent application in chronic diseases or symptoms (Kathe and Kathpalia 2017). Furthermore, * Tanikan Sangnim [email protected] 1
Faculty of Pharmaceutical Sciences, Burapha University, 169, Saensook, Muang, Chonburi 20131, Thailand
Department of Chemical Engineering, Faculty of Engineering, Burapha University, Chonburi 20131, Thailand
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patches are not messy like semisolid formulations but normally cause skin irritation (Dhiman et al. 2011) due to their occlusive properties which can block sweat ducts. Moreover, patches dosage forms are inconvenient for curved surfaces. It is also pain when peeling o
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