Developmental Plasticity of Inhibitory Circuitry
Neuroscience has long been focused on understanding neural plasticity in both development and adulthood. However, experimental work in this area has focused almost entirely on plasticity at excitatory synapses. A growing body of evidence suggests that pla
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Developmental Plasticity of Inhibitory Circuitry
Sarah L. Pallas Editor
Developmental Plasticity of Inhibitory Circuitry
Editor Sarah L. Pallas Georgia State University Dept. Biology 24 Peachtree Center Ave. 428 Kell Hall Atlanta, GA 30303 [email protected]
ISBN 978-1-4419-1242-8 e-ISBN 978-1-4419-1243-5 DOI 10.1007/978-1-4419-1243-5 Springer New York Dordrecht Heidelberg London Library of Congress Control Number: 2009932756 © Springer Science+Business Media, LLC 2010 All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Springer Science+Business Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
Preface
This book was conceived at Watershed Restaurant in Decatur, GA, after a symposium on the topic organized by myself and Pete Wenner for the 2006 Society for Neuroscience meeting in Atlanta (Pallas et al. 2006). Our compliments to Chef Scott Peacock! We put together the symposium because of our own interest in this under-studied topic, relevant findings in our laboratories, and the fact that several mechanistic explanations for plasticity at inhibitory synapses had been uncovered by the invitees. Due in large part to the work of the contributors to the symposium and to this book, inhibitory plasticity is finally becoming widely recognized as a critical area for investigation. Increasing evidence supports an important role for inhibition in disease states, including epilepsy, schizophrenia, and autism spectrum disorders, and one of our aims in this book has been to bring together data from the synaptic and circuit levels of analysis with some of the clinical data in one volume. Some of the authors we invited were ultimately unavailable to contribute chapters, but we had the great good fortune to be able to add several others. As in any collection, however, there are many more investigators and studies that we would like to have included but could not due to lack of space. It has been our goal to provide the reader with a broad overview of mechanisms underlying inhibitory plasticity and of the systems in which it operates. We hope that this book will encourage further study of inhibitory plasticity by other investigators, and that further elucidation of the underlying mechanisms will lead to translational applications. Atlanta, GA
Sarah L. Pallas
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Contents
Background 1
Introduction ........................................
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