Diagnostic criteria of sentinel lymph node micrometastasis or macrometastasis based on tissue rinse liquid-based cytolog
- PDF / 603,052 Bytes
- 6 Pages / 595.276 x 790.866 pts Page_size
- 1 Downloads / 190 Views
ORIGINAL ARTICLE
Diagnostic criteria of sentinel lymph node micrometastasis or macrometastasis based on tissue rinse liquid‑based cytology in gynecological cancer Hiroko Matsumiya1 · Yukiharu Todo1 · Hiroyuki Yamazaki2 · Ryutaro Yamada1 · Kaoru Minowa1 · Tomohiko Tsuruta1 · Hiroyuki Kurosu1 · Shinichiro Minobe1 · Hidenori Kato1 · Hiroaki Suzuki3 · Kiyomi Taira3 · Katsushige Yamashiro3 Received: 18 June 2020 / Accepted: 10 August 2020 © Japan Society of Clinical Oncology 2020
Abstract Objective This study aimed to establish intraoperative diagnostic criteria of sentinel lymph node (SLN) micro-/macrometastasis on the basis of tissue rinse liquid-based cytology (TRLBC) in gynecological cancer. Methods We enrolled 214 patients with gynecological cancer who underwent rapid diagnosis of SLN metastasis on the basis of TRLBC from a total of 490 SLNs. For slides that were classified as positive for atypical cells on cytological inspection, we counted the number of clusters (an atypical cell mass consisted of three or more cells) and the number of single cells (an atypical cell other than clusters). Receiver operating characteristic (ROC) analysis was applied to determine the efficiency of predicting SLN micro-/macrometastasis. Results On cytological inspection, 36 slides were classified as positive for atypical cells, while 21 slides (4.3%) were true positive, 15 (3.1%) were false positive, and 454 (92.6%) were true negative. There were no false negative results in this study. The area under the ROC curve for the number of cluster was superior to that for the number of single cells for distinguishing micro-/macrometastasis from negative/isolated tumor cells (0.86 vs. 0.67, P = 0.032). The optimum cut-off value of the number of clusters was 5 for distinguishing these two categories. Conclusions TRLBC is a highly sensitive alternative for detecting SLN metastasis as a rapid intraoperative diagnosis. Counting the number of atypical cell clusters might be useful for distinguishing micro-/macrometastasis from isolated tumor cells. Keywords Sentinel lymph node · Liquid-based cytology · Isolated tumor cells · Endosalpingiosis · Gynecological cancer
Introduction Sentinel lymph node (SLN) mapping is expected to offer a trade-off between systematic lymphadenectomy and no dissection in patients with early-stage cervical/endometrial cancer [1–7]. However, there is no standard intraoperative * Yukiharu Todo [email protected] 1
Division of Gynecologic Oncology, National Hospital Organization, Hokkaido Cancer Center, 4‑2 Kikusui, Shiroishi‑ku, Sapporo 003‑0804, Japan
2
Department of Obstetrics and Gynaecology, Hokkaido University School of Medicine, Kita‑14, Nishi‑5, Kita‑Ku, Sapporo 060‑8648, Japan
3
Division of Pathology, National Hospital Organization, Hokkaido Cancer Center, 4‑2 Kikusui, Shiroishi‑ku, Sapporo 003‑0804, Japan
diagnostic method for detecting SLN metastasis. A variety of rapid diagnostic methods have been reported, including frozen sections, imprint cytology, immunohistochemistry, and the
Data Loading...
