Diagnostic Testing of COVID-19 in Solid Organ Transplantation: Current Clinical Application and Future Strategies
- PDF / 352,664 Bytes
- 9 Pages / 595.276 x 790.866 pts Page_size
- 34 Downloads / 166 Views
COVID19 AND TRANSPLANTATION (R AVERY, SECTION EDITOR)
Diagnostic Testing of COVID-19 in Solid Organ Transplantation: Current Clinical Application and Future Strategies Paul A. Trubin 1 & Marwan M. Azar 1 & Maricar Malinis 1 Accepted: 12 October 2020 # Springer Nature Switzerland AG 2020
Abstract Purpose of Review While a great deal of literature has been published recently on the viral kinetics of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and diagnostic testing performance for coronavirus disease 2019 (COVID-19) in the general population, a relative paucity of information has come to light regarding implications of COVID-19 diagnostics for solid organ transplantation. This review examines the current state of knowledge regarding the two principal diagnostic testing strategies for SARS-CoV-2 infection, polymerase chain reaction (PCR)–based testing and serology, and discusses COVID-19 diagnostic implications for solid organ transplantation. Recent Findings The interpretation of diagnostics for SARS-CoV-2 infection can present several challenges and raises questions regarding optimal donor and candidate screening as well as infection prevention practices in solid organ transplant recipients with SARS-CoV-2 infection. Guidance from several societies regarding donor and recipient suitability for transplantation during the COVID-19 pandemic is reviewed. Prolonged positive testing by polymerase chain reaction has been described in transplant recipients which may impact infection prevention practices. Summary The COVID-19 pandemic has put multiple aspects of solid organ transplantation at risk, with impacts on donor and recipient suitability, and mitigation of infection and transmission after transplantation. Accumulating evidence regarding diagnostic fidelity and transmissibility of SARS-CoV-2 in immunocompromised patients will continue to inform optimal practices surrounding solid organ transplantation during the COVID-19 pandemic. Keywords COVID-19 . Organ transplant . Screening . Serology . Molecular testing
Introduction The importance of both accurate and precise diagnostic testing for SARS-CoV-2 infection in the current COVID-19 pandemic cannot be overstated. Individual patient care, local outbreak control, and regional and national public health recommendations are critically dependent on accurate and precise diagnostic testing. The development of internally reliable and Marwan M. Azar and Maricar Malinis equally contributed to the manuscript as senior authors. This article is part of the Topical Collection on COVID-19 and Transplantation * Maricar Malinis [email protected] 1
Section of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, PO Box 208022, New Haven, CT 06520-8022, USA
externally validated assays in the midst of a pandemic is an important first step of response that can impact clinical care and infection prevention strategies. Currently available molecular and serologic tests are associated with clinical nuances, and testing
Data Loading...
