Disordered Vertebral and Rib Morphology in Pudgy Mice Structural Rel

This book presents results obtained from the whole mount preparations, radiological, and histological studies of 60 pu/pu and pu/+ mice from late embryo until 3 months of age. Most mice were in the embryo to 6 week age group where vertebral developmental

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Frederic Shapiro

Disordered Vertebral and Rib Morphology in Pudgy Mice Structural Relationships to Human Congenital Scoliosis

Advances in Anatomy, Embryology and Cell Biology publishes critical reviews and state-ofthe-art surveys on all aspects of anatomy and of developmental, cellular and molecular biology, with a special emphasis on biomedical and translational topics. The series publishes volumes in two different formats: • Contributed volumes, each collecting 5 to 15 focused reviews written by leading experts • Single-authored or multi-authored monographs, providing a comprehensive overview of their topic of research Manuscripts should be addressed to Co-ordinating Editor Prof. Dr. H.-W. KORF, Zentrum der Morphologie, Universita¨t Frankfurt, Theodor-Stern Kai 7, 60595 Frankfurt/Main, Germany e-mail: [email protected] Editors ¨ CKERS, Institut fu¨r Anatomie und Zellbiologie, Universita¨t Ulm, Ulm, Germany Prof. Dr. T.M. BO e-mail: [email protected] ´ , Department of Anatomy, Histology and Neurobiology Prof. Dr. F. CLASCA Universidad Auto´noma de Madrid, Ave. Arzobispo Morcillo s/n, 28029 Madrid, Spain e-mail: [email protected] Prof. Dr. Z. KMIEC, Department of Histology and Immunology, Medical University of Gdansk, Debinki 1, 80-211 Gdansk, Poland e-mail: [email protected] Prof. Dr. B. SINGH, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, SK, Canada e-mail: [email protected] Prof. Dr. P. SUTOVSKY, S141 Animal Science Research Center, University of Missouri, Columbia, MO, USA e-mail: [email protected] Prof. Dr. J.-P. TIMMERMANS, Department of Veterinary Sciences, University of Antwerpen, Groenenborgerlaan 171, 2020 Antwerpen, Belgium e-mail: [email protected]

221 Advances in Anatomy, Embryology and Cell Biology

Co-ordinating Editor H.-W. Korf, Frankfurt

Series Editors T.M. Bo¨ckers • F. Clasca´ • Z. Kmiec B. Singh • P. Sutovsky • J.-P. Timmermans More information about this series at http://www.springer.com/series/102

Frederic Shapiro

Disordered Vertebral and Rib Morphology in Pudgy Mice Structural Relationships to Human Congenital Scoliosis

Frederic Shapiro Laboratory for the Study of Skeletal Disorders Harvard Medical School Boston, Massachusetts USA

ISSN 0301-5556 ISSN 2192-7065 (electronic) Advances in Anatomy, Embryology and Cell Biology ISBN 978-3-319-43149-9 ISBN 978-3-319-43151-2 (eBook) DOI 10.1007/978-3-319-43151-2 Library of Congress Control Number: 2016950901 © Springer International Publishing Switzerland 2016 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered