Duloxetine overdose
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Tonic-clonic seizure: case report A 25-year-old man developed a generalised tonic-clonic seizure secondary to an intentional duloxetine overdose. The man presented 12 hours following ingestion of 47 duloxetine 60mg tablets (2820mg). He had recently experienced an episode of major depression. Presenting symptoms included irritability, anxiety, worsening tension and blurred vision which were nonresponsive to IV diazepam. GI decontamination, comprising gastrolavage, activated charcoal and magnesium sulphate, was performed. He subsequently experienced a generalised tonic-clonic seizure 1 hour after gastrolavage (approximately 15 hours since ingestion). The seizure was successfully managed by administration of IV diazepam. The man recovered without further incident and was referred to an ICU for 36 hours’ clinical observation. He was then discharged 72 hours postadmission and prescribed diazepam 30 mg/day. No further seizures had occurred after 3 months follow-up. Pellicciari A, et al. Generalized tonic-clonic seizure secondary to duloxetine poisoning: A short report with favorable out come. Neurotoxicology 33: 189-190, No. 2, Mar 2012. Available from: URL: http://dx.doi.org/10.1016/ 803070861 j.neuro.2012.01.009 - Italy
0114-9954/10/1403-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Reactions 26 May 2012 No. 1403
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