Effect of Bariatric Surgery on Serum Enzyme Status in Obese Patients
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ORIGINAL CONTRIBUTIONS
Effect of Bariatric Surgery on Serum Enzyme Status in Obese Patients Bingsheng Guan 1 & Yanya Chen 2 & Tsz Hong Chong 1 & Juzheng Peng 1 & Tsz Kin Mak 1 & Cunchuan Wang 1 & Jingge Yang 1
# Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract Background Scarce data exists about serum enzyme in bariatric patients. We attempted to evaluate serum enzyme status in patients receiving Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG) and to identify related predictors. Methods We retrospectively reviewed the patients receiving RYGB and SG in our center from January 2013 to January 2018. Anthropometric data and serum enzyme data were collected preoperatively and 6 and 12 months postoperatively. Results Five hundred patients (201 RYGB, 299 SG) were included. Serum enzyme abnormalities were common preoperatively, with 50.8% for elevated alanine aminotransferase (ALT), 33.0% for elevated aspartate aminotransferase (AST), 36.6% for elevated γ-glutamyltranspeptidase (γ-GT), 17.6% for elevated creatine kinase (CK), 15.2% for elevated lactic dehydrogenase (LDH), 9.0% for elevated adenosine deaminase (ADA), 6.2% for elevated hydroxybutyrate dehydrogenase (HBDH), and 8.4% for decreased superoxide dismutase (SOD). After RYGB and SG, the prevalence of serum ALT, AST, γ-GT, LDH, and HBDH abnormalities reduced. The levels of ALT, AST, γ-GT, ADA, cholinesterase (CHE), LDH, CK, and HBDH reduced significantly, while amylase and SOD levels increased. Age and preoperative γ-GT level were independent predictors of ALT, AST, γ-GT, and LDH change 1 year postoperatively. Preoperative ALT, AST, ALP, LDH, and HBDH levels could predict postoperative change, respectively. Gender and surgical procedure could predict postoperative ALP change. Conclusion Serum enzyme abnormalities are common in bariatric surgery candidates, with reduced prevalence of abnormalities postoperatively. RYGB and SG are related with reduced ALT, AST, γ-GT, ADA, CHE, LDH, CK, and HBDH levels, as well as increased amylase and SOD levels. Keywords Bariatric surgery . Serum enzyme . Obesity . Gastric bypass . Sleeve gastrectomy
Introduction Obesity is a common endocrine disorder in both developed and developing countries, which has caused remarkable economic burden to families and societies [1]. As a chronic disease, obesity can result in various obesity-related comorbidities, such as hypertension, hyperlipemia, hyperuricemia, type 2 diabetes mellitus (T2DM), and fatty liver [2]. In addition, it has been observed that obesity was accompanied by some liver enzyme changes. For example, some studies reported higher alanine aminotransferase (ALT) and aspartate aminotransferase (AST) and γglutamyltranspeptidase (γ-GT) [3, 4], while others revealed * Jingge Yang [email protected] 1
Department of Gastrointestinal Surgery, First Affiliated Hospital of Jinan University, Guangzhou 510630, China
2
Department of Nursing Science, School of Nursing, Jinan University, Guangzhou 510632, China
normal AST and γ-GT level in obese patie
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