Effect of Weight Loss Surgery on Biomarkers of Angiogenesis in Obese Patients
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ORIGINAL CONTRIBUTIONS
Effect of Weight Loss Surgery on Biomarkers of Angiogenesis in Obese Patients Maciej Wiewiora 1,2 & Anna Mertas 3 & Marek Gluck 1 & Alicja Nowowiejska-Wiewiora 4 & Zenon Czuba 3 & Jerzy Piecuch 1
# The Author(s) 2020
Abstract Background The present study aims to clarify the effects of weight loss on biomarkers associated with angiogenesis in patients who underwent laparoscopic sleeve gastrectomy (SG) or adjustable gastric banding (LAGB) in the 12-month follow-up study. Materials and Methods We studied 24 obese patients who underwent laparoscopic weight loss surgery, 13 of whom underwent SG and 11 of whom underwent LAGB. We evaluated the circulating level of angiogenesis biomarkers preoperatively and 12 months after surgery. Results Before surgery, the following angiogenic circulating factors were significantly higher than those of healthy subjects: angiopoietin 2 (ANG-2) (p < .05), granulocyte colony-stimulating factor (G-CSF) (p < .05), hepatocyte growth factor (HGF) (p < .01), platelet endothelial cell adhesion molecule (PECAM-1) (p < .01), and vascular endothelial growth factor (VEGF) (p < .05). The following angiogenesis biomarkers decreased significantly after weight loss compared with their baseline values: ANG-2 (p < .05), follistatin (p < .05), HGF (p < .01), PECAM-1 (p < .01), and VEGF (p < .05). There were no significant differences in the circulating levels of angiogenesis biomarkers between individuals who underwent SG and those who underwent LAGB; however, HGF, PECAM-1, and VEGF tended to be lower after SG. %BMI correlated negatively with HGF, PECAM-1, and VEGF. A similar significant negative correlation was found for %WL and %EWL. WHR correlated with PDGF-B and VEGF. Conclusions We concluded that weight loss surgery induces the changes of circulating levels of angiogenesis biomarkers in obese patients. The changes in angiogenesis status in obese patients who lost weight after bariatric surgery depended on the amount of weight loss. Keywords Angiogenesis . Obesity . Bariatric surgery
Introduction Obesity induces adipose tissue dysfunction that typically leads to the overexpression of proinflammatory adipokines, * Maciej Wiewiora
1
Department of General and Bariatric Surgery and Emergency Medicine, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia, Katowice, Poland
2
Department of Cardiac, Vascular and Endovascular Surgery and Transplantology, Zabrze, Poland
3
Department of Microbiology and Immunology, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia, Katowice, Poland
4
Third Department of Cardiology, Silesian Centre for Heart Disease, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia, Katowice, Poland
decreased expression of anti-inflammatory adipokines, and changes in adipose tissue vasculature, depending on factors that affect angiogenesis. There are a large number of factors involved in regulating angiogenesis in adipose tissue that depend on
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