Effect of calcipotriol plus betamethasone dipropionate gel phonophoresis on psoriasis: a single-blind randomized control
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Effect of calcipotriol plus betamethasone dipropionate gel phonophoresis on psoriasis: a single-blind randomized controlled trial Ereny S. Wahba Department of Physical Therapy for Surgery, Faculty of Physical Therapy, Cairo University, Giza, Egypt Correspondence to Ereny S. Wahba, PhD, Faculty of Physical Therapy, Cairo University, ´ lsarayat, Giza 7 Ahmed Alzayate Street, Been U 12111, Egypt. Tel: +20 100 403 7190; fax: 0020237617692; e-mail: [email protected] Received 14 October 2018 Accepted 14 March 2019 Bulletin of Faculty of Physical Therapy 2019, 24:57–65
Background Psoriasis is a common, immune-mediated, inflammatory disease that can affect all aspects of a person’s life including esthetic appearance, relationships with others, and psychological, social, and physical functioning. Objective This study was conducted to investigate the therapeutic benefits of calcipotriol plus betamethasone dipropionate gel (Dovobet gel) phonophoresis in the treatment of plaque psoriasis. Patients and methods Forty patients with a moderate degree of psoriasis (localized psoriasis) were included, and their age ranged from 25 to 45 years. Patients were randomly assigned into two groups: the study group underwent calcipotriol plus betamethasone dipropionate gel phonophoresis and the control group underwent calcipotriol plus betamethasone dipropionate gel. All treatment interventions were applied at a frequency of three sessions per week for 8 weeks. Outcome measures were performed through ultrasound imaging system that was used to measure the thickness of the skin. The assessment was done before treatment and after 8 weeks of the treatment. Results There was a significant decrease in the skin thickness after treatment in the study group compared with that of control group (P 10% (n= 5) • Bacterial skin infections (n= 5) • Don’t agree to participate(n=4)
Pre study assessment of moderate psoriasis by Ultrasound imaging system (n=40)
Dovobet gel phonophoresis (Study group) (n=20)
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Dovobet gel was applied to the affected area. Ultrasound was implemented by the therapist. 3 sessions / week for 8weeks
Dovobet gel (Control group) (n=20)
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Dovobet gel was applied to the affected area. Once per day, for 8weeks. !
Post treatment evaluation of moderate psoriasis and statistical analysis n=40; no drop-out Participant flow chart. Dovobet gel phonophoresis, Dovobet gel only.
thickness between the study and control groups. Paired t-test was conducted for comparison between pretreatment and post-treatment values in each group. The level of significance for all statistical tests was set at P value less than 0.05.
Results A diagram of the patients’ randomization in the study is shown in Fig. 1. A total of 60 patients were initially screened. After the screening process, 40 patients were found to be eligible to participate in the study. In total, 40 (100%) participants completed the treatment program. Demographic data of patients
Table 1 showed the mean±SD age of the study and control groups. There was no significan
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