Effect of sodium acetate on serum activity of glucose-6-phosphate dehydrogenase in Plasmodium berghei -infected mice
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ORIGINAL ARTICLE
Effect of sodium acetate on serum activity of glucose-6-phosphate dehydrogenase in Plasmodium berghei-infected mice A. O. Abdulkareem1,4 • O. A. Babamale2 • L. A. Aishat1 • O. C. Ajayi1 S. K. Gloria1 • L. A. Olatunji3,4 • U. S. Ugbomoiko2
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Received: 23 April 2020 / Accepted: 10 September 2020 Ó Indian Society for Parasitology 2020
Abstract Malaria is a global health problem with severe morbidity and mortality in Sub-Saharan Africa. Resistance of Plasmodium spp to the current anti-malaria drugs necessitates further search for novel effective drugs. This study, therefore, investigated the effect of sodium acetate on glucose-6-phosphate dehydrogenase in Plasmodium berghei-infected mice. Thirty male Albino mice were randomly distributed into 6 groups, A–F. Animals in Groups B–F were inoculated with P. berghei, intraperitoneally. Subsequently, Group C mice were treated with 20 mg/kg chloroquine, while groups D, E and F received 25, 50 and 100 mg/kg sodium acetate, respectively. All treatments were administered orally for 4 days. At the end of the experiment, animals were sacrificed by cervical dislocation and blood was collected via cardiac puncture for the analyses of serum glucose-6-phosphate dehydrogenase (G6PD), uric acid and lipid profile. Our results showed that Sodium acetate (50 and 100 mg/kg) significantly reduced (p \ 0.05) parasitaemia (67.11% and 77.62%, respectively) than chloroquine (61.73%). Besides, body weight and serum G6PD activity in P. berghei infection were improved. Similarly, sodium acetate reduced elevated
& A. O. Abdulkareem [email protected] 1
Animal Physiology Unit, Department of Zoology, University of Ilorin, Ilorin, Nigeria
2
Parasitology Unit, Department of Zoology, University of Ilorin, Ilorin, Nigeria
3
Cardiovascular Research Unit, Department of Physiology, College of Health Sciences, University of Ilorin, Ilorin, Nigeria
4
HOPE Cardiometabolic Research Research Team, University of Ilorin, Ilorin, Nigeria
serum uric acid. Effects of sodium acetate and chloroquine on biochemical parameters were comparable (p [ 0.05) but atherogenic lipid ratios were not affected by sodium acetate. These data put together suggested that activity of sodium acetate may be harnessed for development of novel anti-malaria drugs. However, more studies are required to delineate its mechanisms of action. Keywords Sodium acetate Plasmodium berghei Uric acid Lipid profile G6PD
Introduction Malaria is a serious disease in both tropics and sub-tropics, especially in Africa and Asia, accounting for 93% of malaria global incidence in 2018 (WHO 2019). Despite a significant reduction in disease transmission in many former high incidence settings, only few areas have become malaria-free. Thus, malaria remains a serious health problem with high morbidity and mortality than any other parasitic infections, especially among children and pregnant women (WHO 2015, 2019). The main pathophysiological consequences of malaria are caused by the asexual blood stage of Plasmodium sp
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