Effect of Tryptophan Hydroxylase-2 rs7305115 SNP on suicide attempts risk in major depression
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RESEARCH
Open Access
Effect of Tryptophan Hydroxylase-2 rs7305115 SNP on suicide attempts risk in major depression Yuqi Zhang1*†, Changsong Zhang2†, Guozhen Yuan1†, Jianjun Yao1, Zaohuo Cheng1, Chaojun Liu3, Qinghai Liu3, Gairong Wan3, Guizhi Shi4, Yiren Cheng3, Yang Ling2, Ke Li4
Abstract Background: Suicide and major depressive disorders (MDD) are strongly associated, and genetic factors are responsible for at least part of the variability in suicide risk. We investigated whether variation at the tryptophan hydroxylase-2 (TPH2) gene rs7305115 SNP may predispose to suicide attempts in MDD. Methods: We genotyped TPH2 gene rs7305115 SNP in 215 MDD patients with suicide and matched MDD patients without suicide. Differences in behavioral and personality traits according to genotypic variation were investigated by logistic regression analysis. Results: There were no significant differences between MDD patients with suicide and controls in genotypic (AG and GG) frequencies for rs7305115 SNP, but the distribution of AA genotype differed significantly (14.4% vs. 29.3%, p < 0.001). The G-allele frequency was significantly higher in cases than control group (58.1% vs.45.6%, p < 0.001), but the A-allele carrier indicated a decreased trend in MDD with suicide behaviors than control group (41.9% vs.54.4%, p < 0.001). The multivariate logistic regression analysis indicated that TPH2 rs7305115 AA (OR 0.33, 95% CI 0.22-0.99), family history of suicide (OR 2.98, 95% CI 1.17-5.04), negative life events half year ago (OR 6.64, 95% CI 2.48-11.04) and hopelessness (OR 7.68, 95% CI 5.79-13.74) were significantly associated with the suicide behaviors in MDD patients. Conclusions: The study suggested that hopelessness, negative life events and family history of suicide were risk factors of attempted suicide in MDD while the TPH2 rs7305115A remained a significant protective predictor of suicide attempts.
Background Suicide is an important public health problem and ranks among the top 10 causes of death for individuals of all ages and major depressive disorders (MDD) appeared to confer greater risk for suicide [1,2]. Suicidal behavior is commonly considered to result from an interaction of genetic, neurobiological, and psychosocial factors. Genetic risk factors are estimated to account for approximately 30% to 40% of the variance in suicidal behavior, however the precise mechanism of the genetic contribution are unknown [3]. Dysregulation of brain serotonin contributes to many psychiatric disorders. Furthermore, abnormal serotonergic function has frequently been reported in individuals * Correspondence: [email protected] † Contributed equally 1 Wuxi Psychiatric Hospital, Nanjing Medical University, Wuxi, China Full list of author information is available at the end of the article
who commit or attempt suicide and is one of the most replicated findings in modern biological psychiatry [4]. For example, low levels of serotonin (5-hydroxytryptamine, 5-HT) have also been observed in suicide victims and 5-HT could play a role in the predisposit
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