Efficacy and safety of oxygen-sparing nasal reservoir cannula for treatment of pediatric hypoxemic pneumonia in Uganda:
- PDF / 1,857,853 Bytes
- 12 Pages / 595.276 x 790.866 pts Page_size
- 25 Downloads / 170 Views
RESEARCH ARTICLE
Open Access
Efficacy and safety of oxygen-sparing nasal reservoir cannula for treatment of pediatric hypoxemic pneumonia in Uganda: a pilot randomized clinical trial Jerry Mulondo1, Stella Maleni1, Hellen Aanyu-Tukamuhebwa2, Ezekiel Mupere2,3, Alfred Onubia Andama4, Chin Hei Ng5, Stephen Burkot5, Ella M. E. Forgie6, Qaasim Mian6, Christine M. Bachman5, Gerard Rummery7, Daniel Lieberman5, David Bell5,8, Michael T. Hawkes6,9,10,11,12*† and Akos Somoskovi5†
Abstract Background: Oxygen is an essential therapy for hypoxemia but is scarce in low-income settings. Oxygen conserving devices optimize delivery, but to date have been designed for adults in high-income settings. Here we present the development and clinical pilot study of an oxygen-sparing nasal reservoir cannula (OSNRC) for pediatric use in low-income settings. Methods: (1) Pre-clinical development of a novel OSNRC using a simulated respiratory circuit with metabolic simulator and anatomically accurate face-airway models. Simulated breathing waveforms were designed based on airway resistance, lung compliance, respiratory rate, and tidal volume of spontaneous breathing for three disease conditions. (2) Pilot, randomized, controlled, non-blinded, cross-over study of the OSNRC vs standard nasal cannula (SNC) among children hospitalized with hypoxemic pneumonia in Uganda. Eight children were randomized to OSNRC followed by SNC, and eight were randomized to SNC followed by OSNRC. (Continued on next page)
* Correspondence: [email protected] † Michael T. Hawkes and Akos Somoskovi contributed equally to this work. 6 Department of Pediatrics, University of Alberta, 3-588D Edmonton Clinic Health Academy, 11405 87 Ave NW, Edmonton, Alberta T6G 1C9, Canada 9 Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, Canada Full list of author information is available at the end of the article © The Author(s). 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
Mulondo et al. BMC Pulmonary Medicine
(2020) 20:230
Page 2 of 12
Data Loading...
