Emerging Role of SIGIRR rs7396562(T/G) Polymorphism in Systemic Lupus Erythematosus in a Chinese Population
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Emerging Role of SIGIRR rs7396562(T/G) Polymorphism in Systemic Lupus Erythematosus in a Chinese Population Yan Zhu,1,2 De-Guang Wang,1,3 Xiao-Ke Yang,1,2 Sha-Sha Tao,1,2 Qing Huang,1,2 Hai-Feng Pan,1,2 Chen-Chen Feng,1,2 and Dong-Qing Ye1,4
Abstract—Systemic lupus erythematosus (SLE) is a systemic autoimmune disease, with heterogeneous presentation. The aim of this study was to examine the association of a single-nucleotide polymorphism, rs7396562, of the interferon induced with single immunoglobulin IL-1-related receptor (SIGIRR) gene with SLE in a Chinese population. A total of 741 SLE patients and 731 healthy control subjects were enrolled in the present study. The genotyping of polymorphism (rs7396562) was determined by TaqMan allele discrimination assay on the 7,300 real-time polymerase chain reaction system. The frequency of T allele for rs7396562 in patients was significantly higher than in controls (T versus G, OR=1.318, 95 % confidence interval (CI)=1.139–1.525, P0.05. Association of SIGIRR rs7396562 Polymorphism with Risk of SLE The allele T frequency of SNP rs7396562 was significantly higher in SLE patients compared to controls (P
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