Endurance Exercise Intervention Is Beneficial to Kidney Function in a Rat Model of Isolated Abdominal Venous Congestion:
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ORIGINAL ARTICLE
Endurance Exercise Intervention Is Beneficial to Kidney Function in a Rat Model of Isolated Abdominal Venous Congestion: a Pilot Study Jirka Cops 1,2 & Bart De Moor 1,3 & Sibren Haesen 1,2 & Lien Lijnen 1 & Inez Wens 4 & Lieselotte Lemoine 1,5 & Carmen Reynders 6 & Joris Penders 1,6 & Ivo Lambrichts 1 & Wilfried Mullens 1,7 & Dominique Hansen 1,8,9 Received: 2 October 2019 / Accepted: 9 December 2019 # Springer Science+Business Media, LLC, part of Springer Nature 2019
Abstract In this study, the effects of moderate intense endurance exercise on heart and kidney function and morphology were studied in a thoracic inferior vena cava constricted (IVCc) rat model of abdominal venous congestion. After IVC surgical constriction, eight sedentary male Sprague-Dawley IVCc rats (IVCc-SED) were compared to eight IVCc rats subjected to moderate intense endurance exercise (IVCc-MOD). Heart and kidney function was examined and renal functional reserve (RFR) was investigated by administering a high protein diet (HPD). After 12 weeks of exercise training, abdominal venous pressure, indices of body fat content, plasma cystatin C levels, and post-HPD urinary KIM-1 levels were all significantly lower in IVCc-MOD versus IVCc-SED rats (P < 0.05). RFR did not differ between both groups. The implementation of moderate intense endurance exercise in the IVCc model reduces abdominal venous pressure and is beneficial to kidney function. Keywords Abdominal venous congestion . Moderate intense endurance exercise training . Cardiac function, renal function, rat model
Abbreviations ALT Alanine aminotransferase AST Aspartate aminotransferase Wilfried Mullens and Dominique Hansen contributed equally to this work. Statement clinical relevance This study provides relevant insight concerning the impact of moderate intense endurance exercise training on the development of abdominal venous congestion and the progression of kidney dysfunction. Associate Editor Domingo A. Pascual-Figal oversaw the review of this article Electronic supplementary material The online version of this article (https://doi.org/10.1007/s12265-019-09947-5) contains supplementary material, which is available to authorized users. * Jirka Cops [email protected] Extended author information available on the last page of the article
ATIIT1R ATP AWT BSA CO CRP CVP EDV EF ESV FENa G GFR HPD HR IVCc IVCc-MOD IVCc-SED KIM-1 LVEDD LVEDP LVESD LVP NO
Angiotensin II type 1 receptor Adenosine triphosphate Anterior wall thickness Bovine serum albumin Cardiac output C-reactive protein Central venous pressure End-diastolic volume Ejection fraction End-systolic volume Fractional excretion of sodium Gauge (needle diameter) Glomerular filtration rate High protein diet Heart rate Inferior vena cava constriction IVCc rats subjected to moderate intense endurance exercise Sedentary IVCc rats Kidney injury molecule 1 Left ventricular end-diastolic diameter Left ventricular end-diastolic pressure Left ventricular end-systolic diameter Left ventricular pressure Nitric oxide
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