Eosinophilic Esophagitis: the Potential Role of Biologics in its Treatment
- PDF / 496,106 Bytes
- 10 Pages / 595.276 x 790.866 pts Page_size
- 83 Downloads / 217 Views
Eosinophilic Esophagitis: the Potential Role of Biologics in its Treatment Shelly Choudhury 1
&
Susan Baker 2
# Springer Science+Business Media, LLC, part of Springer Nature 2019
Abstract Eosinophilic esophagitis (EoE) is a chronic, relapsing inflammatory disease of the esophagus, characterized by the presence of significant esophageal mucosal eosinophilic infiltrates. The clinical presentation of EoE in childhood may include failure to thrive and feeding intolerance. The complication of food impaction is often related to the presence of strictures or narrow caliber esophagus. Over the last decade, there has been tremendous progress in the field of eosinophilic disorders, particularly eosinophilic esophagitis. Conventional treatment of eosinophilic esophagitis involves topical swallowed steroids, systemic steroids, elimination diets, and/or esophageal dilation. However, treatment outcomes with the above modalities are not satisfactory for all patients with EoE and alternative treatments are clearly needed. There has been ongoing research targeting the treatment-refractory population of patients with EoE and the population with long-term consequences of the disease and its treatment. With the significant eosinophilic infiltration that characterizes EoE, anti-IL-5 therapies designed to target eosinophilic inflammation have been some of the most studied anti-inflammatory biologic therapies in EoE. In the studies published to date, while various IL-5 inhibitors have decreased the numbers of esophageal eosinophils, they have not depleted them to the levels consistent with histologic remission of EoE. As additional biologics that modulate Th2-mediated immunity are trialed for the treatment of EoE, we stand to learn more about the inflammatory factors mediating this challenging condition. In this review, we discuss the alternative modes of therapy in EoE that have emerged, with a focus on anti-IL-5 therapies and other biologics, their variation of success, and ultimately, the future of treatment in this field. Keywords Eosinophilic esophagitis . Eosinophils . Anti-IL-5 . Anti-IgE . Anti IL-13 . Anti-CRTH . Anti-TNF-alpha
Introduction The study of eosinophilic esophagitis (EoE) is a dynamic field that has evolved in the last two decades. The knowledge about the pathophysiologic significance of esophageal eosinophils led to the emergence of this disease entity distinct from gastroesophageal reflux disease. EoE is a hereditable atopic disease, with an increasing prevalence in the western world [1].
* Shelly Choudhury [email protected] 1
Division of Gastroenterology, Department of Pediatrics, Loma Linda University Children’s Hospital, 11234 Anderson St., Loma Linda, CA 92354, USA
2
Division of Gastroenterology, Department of Pediatrics, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY, USA
However, the observed rise in the diagnoses of EoE could also be a result of increased screening or identification. In order to establish diagnostic and treatment criterion, a task force of 31
Data Loading...
