Evaluation of Anti-inflammatory Activity and In Vitro Drug Release of Ibuprofen-Loaded Nanoparticles Based on Sodium Alg
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RESEARCH ARTICLE-CHEMICAL ENGINEERING
Evaluation of Anti‑inflammatory Activity and In Vitro Drug Release of Ibuprofen‑Loaded Nanoparticles Based on Sodium Alginate and Chitosan Sarra Bensouiki1 · Fouzia Belaib1 · Michèle Sindt2 · Pierre Magri2 · Sandrine Rup‑Jacques2 · Chawki Bensouici3 · Abdeslam‑Hassen Meniai1 Received: 31 January 2020 / Accepted: 14 June 2020 © King Fahd University of Petroleum & Minerals 2020
Abstract Ionotropic gelation followed by polyelectrolyte complexion was used for the synthesis of nanoparticles based on sodium alginate (NaAL) and chitosan (CS) for encapsulation of ibuprofen (IBP), Fourier transform infrared spectroscopy, differential scanning calorimetry, field-emission scanning electron microscopes, percentage of encapsulation efficiency and loading capacity have been used to confirm the synthesis and encapsulation of IBP. The results obtained show that they have a size of around 100 nm. In vitro drug release and evaluation of anti-inflammatory activity in different media indicate that the nanoparticles are pH-sensitive and permit the protection of the drug against total dissolution in the gastric medium, control its release, and it increases the solubility and biological activity of IBP. The analytical data of the in vitro drug release in the simulated gastric fluid (SGF), simulated interstitial fluid (SIF) and phosphate buffered saline (PBS) were fitted to the different kinetic models (zero-order, first-order, Higuchi, Korsmeyer–Pepass and Kopcha), and the results indicate that IBP is released by diffusion-controlled in SIF and PBS, and by erosion-controlled in the SGF. The toxicity of nanoparticles was tested against Artemia salina that displayed non-toxicity effects. In vitro biodegradation by lysozyme and all the results obtained indicated that a NaAL/CS nanoparticles are a promising system for IBP release that can achieve pseudo-zero-order kinetics. Keywords Sodium alginate · Chitosan · Ibuprofen · Anti-inflammatory activity · Ionotropic gelation
1 Introduction Ibuprofen (IBP) is a nonsteroidal anti-inflammatory drug (NSAID) classified in category II “highly permeable but poor water solubility” according to biopharmaceutics classification system (BCS) which classifies drugs according to solubility and permeability. This low solubility limits its dissolution rate and hence its oral bioavailability. Short half-life plasma (1–3 h) of IBP leads to multiple administrations that * Fouzia Belaib fouzia.belaib@univ‑constantine3.dz 1
Laboratory of Environmental Process Engineering, Faculty of Process Engineering, University Salah Boubnider − Constantine 3, 25000 Constantine, Algeria
2
Laboratoire de Chimie et Physique: Approche Multi‑échelles des Milieux Complexes, Institut Jean Barriol, Université de Lorraine, Metz 57070, France
3
Biotechnology Research Center, P.B E73/UV N° 03 Ali Mendjeli New Town, 25000 Constantine, Algeria
can cause real problems such as gastric irritation, dyspepsia and even gastric bleeding [1]. To enhance the biological activity of IBP and incre
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