Evaluation of liver function using the hepatocyte enhancement fraction based on gadoxetic acid-enhanced MRI in patients
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HEPATOBILIARY
Evaluation of liver function using the hepatocyte enhancement fraction based on gadoxetic acid‑enhanced MRI in patients with chronic hepatitis B Mao‑Tong Liu1 · Xue‑Qin Zhang1 · Jian Lu1 · Tao Zhang1 · Qi Chen2 · Ji‑Feng Jiang1 · Ding Ding1 · Sheng Du1 · Wei‑Bo Chen3
© Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract Objectives This study aimed to evaluate the feasibility of using the hepatocyte enhancement fraction (HEF) based on gadoxetic acid-enhanced magnetic resonance imaging (MRI) for assessing the liver function in patients with chronic hepatitis B. Methods Sixty patients with Child–Pugh grade A (CP-A), 18 with Child–Pugh grade B (CP-B), 2 with Child–Pugh grade C (CP-C), and 20 with normal liver function (NLF) were enrolled. Gadolinium ethoxybenzyldiethy-lenetriaminepentaacetic acid (Gd-EOB-DTPA)-enhanced MRI was conducted. T1 mapping imaging was performed before and 20 min after Gd-EOBDTPA administration. The pre- and post-contrast T1 values of the liver (T1pre and T1post), increase in the T1 relaxation rate (ΔR1), rate of decrease in the T1 relaxation time (ΔT1), HEF, and uptake coefficient (K) parameters in the NLF, CP-A, and CP-B + CP-C groups were compared using one-way analysis of variance. The effectiveness of each parameter in differentiating the NLF + CP-A group from the CP-B + CP-C group was evaluated using the receiver operating characteristic (ROC) curve. Results The HEF, K, ΔT1, and ΔR1 values decreased, while the T1post and T1pre values increased, with the increase in liver function damage. Significant differences in T1post, ΔT1, ΔR1, and HEF were found between different groups, except for the CP-A and NLF groups. However, no significant difference was observed in the T1pre among the three groups. HEF exhibited the largest area under the ROC curve. Conclusion The HEF is an effective method for evaluating liver function in patients with hepatitis B. Keywords Gd-EOB-DTPA · Liver function · Magnetic resonance imaging
* Xue‑Qin Zhang [email protected]
Sheng Du [email protected]
* Jian Lu [email protected]
Wei‑Bo Chen [email protected]
Mao‑Tong Liu [email protected]
1
Tao Zhang [email protected]
Department of Radiology, Affiliated Nantong Hospital 3 of Nantong University, #99 Youth Middle Road, Chongchuan District, Nantong 226000, Jiangsu, China
2
Qi Chen [email protected]
Nantong University, #19 Qixiu Road, Chongchuan District, Nantong 226000, Jiangsu, China
3
Philips Healthcare, Shanghai, China
Ji‑Feng Jiang [email protected] Ding Ding [email protected]
13
Vol.:(0123456789)
Abdominal Radiology
Introduction
Patient group
At present, liver cancer is the most common malignancy with the highest mortality rate in China [1]. It is also one of the leading causes of death in the world [2]. Surgical resection is the only effective treatment for liver cancer. However, liver failure after hepatectomy is a serious complication of this surgical treatment [3–5]. Therefore, preoperative assessment of liver function is of great si
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