Evaluation of periodontal status and cytokine/chemokine profile of GCF in patients with severe congenital neutropenia
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ORIGINAL ARTICLE
Evaluation of periodontal status and cytokine/chemokine profile of GCF in patients with severe congenital neutropenia Buket Acar1 · Deniz Çağdaş Ayvaz2 · Çağman Tan2 · Begüm Özbek2 · İsmail Yaz2 · Yağmur Deniz Yıldırım1 · Cansu Özşin‑Özler3 · Betül Karaatmaca2 · Pınar Gür‑Çetinkaya2 · Elif Soyak2 · Erdem Karabulut4 · İlhan Tezcan2 · Ezel Berker1 Received: 18 July 2020 / Accepted: 18 October 2020 © The Society of The Nippon Dental University 2020
Abstract Severe congenital neutropenia (SCN) is a primary immunodeficiency characterized by defect in neutrophil count. Increased risk of infections in addition to periodontal problems, such as ulcerations of oral mucosa, gingival inflammation, and rapid loss of attachment are common in the course of the disease. The aim of the present study is to define the causal relationship between the severity of periodontal inflammation and severe congenital neutropenia through identification of cytokine profile in gingival crevicular fluid (GCF). A case–control study was performed in patients diagnosed with SCN and healthy controls. Demographic data, the molecular defect, laboratory work-up were gathered from the hospital registry. Periodontal indices were recorded and GCF samples were analyzed using multiplex analysis for the simultaneous measurements of the particular cytokines and chemokines. The present study included 14 patients and 22 control subjects. Both groups were comparable in terms of age and sex. Severity of gingival inflammation measured by the criteria of Löe was higher in the SCN cases (p
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