Evaluation of sleep-related respiratory disorders in patients with multiple sclerosis
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ORIGINAL ARTICLE
Evaluation of sleep‑related respiratory disorders in patients with multiple sclerosis Hikmet Saçmacı1 · Nermin Tanık1 · Seda Sabah Özcan1 · Yavuz Selim İntepe1 · Tülin Aktürk1 · Bülent Çiftçi1 · Levent Ertuğrul İnan1 Received: 3 October 2019 / Accepted: 23 October 2019 © Belgian Neurological Society 2020
Abstract Patients with multiple sclerosis (MS) often report fatigue, poor sleep and complaint of sleep disorders. Neurofilament light chain (NF-L) has been identified as a potential biomarker for disease progression in MS patients. In this study, we aimed to evaluate sleep characteristics in MS patients and its relationship with the level of serum NF-L. In the present study carried out as a prospective and cross-sectional study, 32 relapsing–remitting MS (RRMS) patients and 32 control subjects were included. Epworth Sleepiness Scale and Fatigue Severity Scale tests were applied to the groups and the full night polysomnography was performed. Serum samples were obtained for NF-L analysis. Apnea–hypopnea index (AHI), AHI in rapid eye movement sleep (AHI REM), percentage of NonREM stage 1 (N1) and NonREM stage 3 (N3) values were significantly different in RRMS patients (p
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