Evaluation of variability of phase indices of the left ventricle in the course of time
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ORIGINAL ARTICLE
Evaluation of variability of phase indices of the left ventricle in the course of time Ozdes Emer • Alper O. Karacalioglu Erol Gursoy • Semra Ince
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Received: 8 April 2014 / Accepted: 6 July 2014 / Published online: 10 July 2014 Ó The Japanese Society of Nuclear Medicine 2014
Abstract Objective Since the effect of time on phase indices is still unclear, the aim of the study was to evaluate the variability of phase indices of the left ventricle which were derived from stress and rest single-photon emission computed tomography (SPECT) imaging acquired at early and late times. Methods One hundred twenty-one patients (72 men, 49 women) were included into the study. All stress and rest gated myocardial perfusion imaging (gMPI) acquisitions were acquired at two different time points as early in 15 ± 5 min and late in 45 ± 5 min. The peak of the phase histogram (PP), the standard deviation of the phase distribution (SDPH), the width of the band (BPH), and the symmetry (histogram skewness, HS) and peakedness of the phase histogram (histogram kurtosis, HK) which are the parameters for assessing left ventricular systolic dyssynchrony were calculated in all stress and rest SPECT images acquired twice. Results The phase indices derived from the late rest scans were smaller than those of the early rest scans but, the differences were not significant. When considering the comparisons of phase indices derived from two different time points after stress, PP showed a tendency to decrease (from 160.8 ± 18.3 to 152.5 ± 17.3; p \ 0.001) over time but SDPH (from 20.2 ± 10.6 to 22.4 ± 12.2; p = 0.018) and BPH (from 61.5 ± 36.0 to 66.3 ± 37.3; p = 0.045) O. Emer A. O. Karacalioglu S. Ince (&) Department of Nuclear Medicine, Gu¨lhane Military Medical Academy and School of Medicine, Etlik, Ankara 06018, Turkey e-mail: [email protected] E. Gursoy Department of Cardiology, Gulhane Military Medical Academy and School of Medicine, Etlik, Ankara, Turkey
tended to increase over time. When the post-stress and the resting dyssynchrony parameters derived at two different time points were compared to each other; PP decreased at early and late times approximately 12 and 9 %, respectively, SDPH increased at early and late times approximately 28.5 and 14 %, respectively, and BPH increased at early and late times approximately 23 and 12 %, respectively. Conclusions In resting conditions, phase indices of the left ventricle, and therefore, the phase histogram tend to remain constant over time but, in conditions after exercise, the phase histogram tend to be long and narrow due to changes in phase indices and it shows tendency to return to resting conditions in time. Therefore, it appears that postexercise acquisition times should be standardized if we want to compare the phase indices results of the studies in the literature. Keywords Gated myocardial perfusion imaging SPECT Phase analysis Dyssynchrony of the left ventricle
Introduction Gated myocardial perfusion imaging (gMPI) with singlephoton emission computed tomography
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