Exacerbated hemodynamic response during exercise in cancer patients prior to autologous hematopoietic stem cell transpla
- PDF / 317,993 Bytes
- 8 Pages / 595.276 x 790.866 pts Page_size
- 99 Downloads / 159 Views
ORIGINAL ARTICLE
Exacerbated hemodynamic response during exercise in cancer patients prior to autologous hematopoietic stem cell transplantation Ana Luiza Machado Dias 1 & Mateus Camaroti Laterza 1 & Pedro Augusto de Carvalho Mira 1,2 & Isabelle Magalhães Guedes Freitas 3 & Patrícia Fernandes Trevizan 1 & Daniel Godoy Martinez 1 & Leonardo Barbosa de Almeida 1 Received: 1 September 2020 / Accepted: 23 November 2020 # Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract Purpose Chemotherapy treatment can lead to cardiovascular toxicity and physical impairment prior to autologous hematopoietic stem cell transplantation (auto-HSCT). Cardiovascular adjustments during exercise and the exercise capacity remain unknown in patients prior to auto-HSCT. Thus, the hemodynamic responses during exercise and exercise capacity were evaluated using a novel effort test in patients prior to auto-HSCT. Methods Thirty patients prior to auto-HSCT (BMT group: 44.6 ± 14.1 years) and 23 control participants (CON group: 43.9 ± 16.6 years) performed the 6-Minute Step Test (6MST) to assess their exercise capacity and the hemodynamic responses during exercise. Systolic and diastolic blood pressure (SBP and DBP), heart rate (HR), and oxygen saturation (SpO2) were measured during the test. Rate-pressure product (RPP) was calculated multiplying SBP by HR. The highest HR value recorded during the test was compared with the maximum HR predicted by age and was used as % of maximum HR (%HRmax). Results The number of steps up and down performed by the BMT group was lower than CON (108.8 ± 25.3 vs. 127.5 ± 34.4 steps, P = 0.02). The BMT group showed a higher magnitude of increase in SBP and RPP during the 6MST when compared to CON (ΔSBP: 18.5 ± 11.45 vs. 8.30 ± 18.46 mmHg, P = 0.01; and ΔRPP: 8197.3 ± 3829.1 vs. 6170.9 ± 3568.9 mmHg beats min−1, P = 0.05). The BMT group exhibited higher SpO2 and HR values throughout the protocol (P < 0.05), reaching a higher %HRmax than CON group (76.9 ± 9.6 vs. 66.4 ± 8.9%, P < 0.01). Conclusions Patients with indication for auto-HSCT have exacerbated chronotropic and pressor responses during exercise and reduced exercise capacity in the 6MST. Keywords Hematopoietic stem cell transplantation . Exercise tolerance . Physical functional performance . Cardiotoxicity
Introduction Hematological malignancies refer to a group of diseases originating from hematopoietic cells, determining a state of differentiation and cellular transformation in the phenotype of these
* Leonardo Barbosa de Almeida [email protected] 1
Cardiovascular Research Unit and Exercise Physiology, Federal University of Juiz de Fora, Juiz de Fora, Brazil
2
Laboratory of Exercise Sciences, Department of Physiology and Pharmacology, Fluminense Federal University, Niteroi, Brazil
3
Faculty of Medical and Health Sciences, SUPREMA, Juiz de Fora, MG, Brazil
diseases, which are expressed by changes located in the blood or in the tissues that form it [1, 2]. Among these diseases, lymphomas and multiple myeloma correspond to the 7th mo
Data Loading...
