Exercise training affects hemodynamics not cardiac function during anthracycline-based chemotherapy
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CLINICAL TRIAL
Exercise training affects hemodynamics not cardiac function during anthracycline‑based chemotherapy Amy A. Kirkham1 · Sean A. Virani2 · Kelcey A. Bland3 · Donald C. McKenzie2 · Karen A. Gelmon2,4 · Darren E. R. Warburton2 · Kristin L. Campbell2 Received: 27 January 2020 / Accepted: 20 July 2020 © Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract Introduction Preclinical data demonstrate the potential for exercise training to protect against anthracycline-related cardiotoxicity, but this remains to be shown in humans. Purpose To assess whether exercise training during anthracycline-based chemotherapy for treatment of breast cancer affects resting cardiac function and hemodynamics. Methods In this prospective, non-randomized controlled study, 26 women who participated in aerobic and resistance training 3×/wk during chemotherapy were compared to 11 women receiving usual care. Two-dimensional echocardiography was performed before and 7–14 days after completion of anthracycline-based chemotherapy. Pre- and post-anthracycline cardiac function and hemodynamic variables were compared within each group with paired t-tests; the change was compared between groups using ANCOVA with adjustment for baseline values. Results Left ventricular longitudinal strain, volumes, ejection fraction, E/A ratio, and mass did not change in either group. Hemoglobin, hematocrit, and mean arterial pressure decreased significantly from baseline in both groups (all p
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