Exploring the efficacy of using hypertonic saline for nebulizing treatment in children with bronchiolitis: a meta-analys
- PDF / 2,842,240 Bytes
- 15 Pages / 595.276 x 790.866 pts Page_size
- 64 Downloads / 180 Views
RESEARCH ARTICLE
Open Access
Exploring the efficacy of using hypertonic saline for nebulizing treatment in children with bronchiolitis: a meta-analysis of randomized controlled trials Chia-Wen Hsieh1,2†, Chiehfeng Chen3,4,5,6†, Hui-Chuan Su1,2 and Kee-Hsin Chen1,2,4,7*
Abstract Background: Inhaled hypertonic saline (HS) has shown benefit in decreasing airway edema in acute bronchiolitis which is the most common lower respiratory infection resulting in dyspnea among infants under 2 years old. The aim of this systematic review and meta-analysis was to evaluate the efficacy and safety of HS in the implementation of treatment with nebulized HS among children with bronchiolitis. Methods: A systematic literature search was conducted using Cochrane Library, PubMed, EMBASE and Airiti Library (Chinese Database) for randomized controlled trials from inception to July 2019. We calculated pooled risk ratios (RR), mean difference (MD) and 95% CI using RevMan 5.3 for meta-analysis. Results: There were 4186 children from 32 publications included. Compared to the control group, the HS group exhibited significant reduction of severity of respiratory distress, included studies used the Clinical Severity Score (n = 8; MD, − 0.71; 95% CI, − 1.15 to − 0.27; I2 = 73%) and full stop after Respiratory Distress Assessment Instrument (n = 5; MD, − 0.60; 95% CI, − 0.95 to − 0.26; I2 = 0%) for evaluation respectively. Further, the HS group decreased the length of hospital stay 0.54 days (n = 20; MD, − 0.54; 95% CI, − 0.86 to − 0.23; I2 = 81%). Conclusions: We conclude that nebulization with 3% saline solution is effective in decreasing the length of hospital stay and the severity of symptoms as compared with 0.9% saline solution among children with acute bronchiolitis. Further rigorous randomized controlled trials with large sample size are needed. Keywords: Bronchiolitis, Children, Hypertonic saline, Nebulizer treatment, Length of hospital stay, Efficacy
Background Bronchiolitis is the most common lower-respiratory infection in infants, affecting 68.8% of infants and neonates aged < 12 months [1, 2], and is a major cause of hospitalization in children during the first year of life [3, 4]. Bronchiolitis is * Correspondence: [email protected] † Chiehfeng Chen is the author contributed equally to the first author. 1 Department of Nursing, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan 2 Center for Nursing and Healthcare Research in Clinical Practice Application, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan Full list of author information is available at the end of the article
primarily caused by viral infection which results in inflammation of the bronchioles in the lungs [5, 6]. The infection can last 2 ~ 3 weeks, and causes mucosal congestion and sputum secretion during the disease course [7, 8]. Common symptoms include excessive coughing with tachypnea, fever and wheezing [1, 9]. In case of severe nasal congestion, a child might resort to open-mouth breathing and prone to dyspnea caused by tracheal obstruct
Data Loading...
