Exploring the prognostic significance of preoperative high normocalcemia in epithelial ovarian carcinoma
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GYNECOLOGIC ONCOLOGY
Exploring the prognostic significance of preoperative high normocalcemia in epithelial ovarian carcinoma Hyun‑Woong Cho1 · Yung‑Taek Ouh1,2 · Jin Hwa Hong1 · Jae Kwan Lee1 Received: 2 April 2020 / Accepted: 7 October 2020 © Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract Purpose We investigated the association between serum ionized calcium and prognosis of EOC and determined the optimal cutoff value of ionized calcium level to predict the prognosis of EOC. Methods The medical records of patients who were newly diagnosed with EOC from 2001 to 2016 were retrieved. Preoperative ionized calcium test was performed within 2 weeks before surgery, and the cutoff of high normocalcemia was defined based on the receiver operating characteristic (ROC) curve for recurrence. Cox proportional hazards regression models were used to identify independent prognostic factors for progression-free survival (PFS). Results From 2001 to 2016, 83 patients diagnosed with EOC were identified at a single institution. The optimal cutoff value was set to 4.7 mg/dL (high normocalcemia vs. control group) by plotting the ROC curve for recurrence. Stages III/IV were more frequent in high normocalcemia, with borderline significance (72.9% vs. 52.2%, p = 0.053). Recurrence (67.6% vs. 43.5%, p = 0.029) and death (46.0% vs. 15.2%, p 1 cm (HR 3.79, 95% CI 1.61–8.95, p 4.7 mg/dL) and low normocalcemia (≤ 4.7 mg/dL). Median age of overall patients was 52.3 ± 11.8 years, and median follow-up period was 62.2 ± 38.2 months. There were no differences in the age, parity, body mass index
(BMI), grade, histology, CA-125, residual tumor, malignant ascites, lymph node metastasis, and follow-up period between the two groups. Stages III/IV were more frequent in high normocalcemia, with borderline significance (72.9% vs. 52.2%, p = 0.053). Recurrence (67.6% vs. 43.5%, p = 0.029) and death (46.0% vs. 15.2%, p
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