Fentanyl
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Fentanyl Diaphoresis following transdermal administration: case report A 53-year-old woman, who had hypochondrium pain due to liver metastases, was receiving transdermal fentanyl (100 mcg/h) that had been increased in dose over the past 10 weeks [initial dosage not stated]. On presentation at a clinic, she reported profuse diaphoresis, which she had noticed over the previous few weeks [duration of treatment before reaction onset not clearly stated]; she reported the diaphoresis as being as if she had ‘had a shower’. Fentanyl was switched to slow-release morphine. After 2 weeks, her pain control had improved greatly and her symptom of ‘drenching sweat’ had dramatically resolved. For the next 6 weeks until her death, she had no more diaphoresis. Author comment: "[T]he temporal relationship of occurrence of sweating with increasing doses of transdermal fentanyl, the absence of any other cause of sweating, and it resolution on changing to oral morphine sulphate make fentanyl the most likely cause." Shah S. Resolution of sweating after switching from transdermal fentanyl to oral morphine sulphate. Palliative Medicine 20: 222, No. 3, 2006 801041793 England
0114-9954/10/1114-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Reactions 12 Aug 2006 No. 1114
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