Four-Dimensional Echocardiographic Evaluation of Left Ventricular Systolic Functions in Patients with Chronic Myeloid Le
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Four‑Dimensional Echocardiographic Evaluation of Left Ventricular Systolic Functions in Patients with Chronic Myeloid Leukaemia Receiving Tyrosine Kinase Inhibitors Ugur Nadir Karakulak1 · Elifcan Aladag2 · Vedat Hekimsoy1 · Mehmet Levent Sahiner1 · Ergun Baris Kaya1 · Necla Ozer1 · Salih Aksu2 · Haluk Demiroglu2 · Hakan Goker2 · Yahya Buyukasik2 · Osman Ozcebe2 · Nilgun Sayinalp2 · Ibrahim Celalettin Haznedaroglu2 Received: 2 June 2020 / Accepted: 10 October 2020 © Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract Tyrosine kinase inhibitors (TKIs) are established treatment for haematological malignancies. However, cardiac adverse effects, including the reduction in left ventricular ejection fraction and symptomatic heart failure remain clinical problems. The purpose of this study was to evaluate the left ventricular systolic functions in patients with chronic myeloid leukaemia receiving TKIs. A cross-sectional and observational study was conducted of 37 patients with chronic myeloid leukaemia receiving dasatinib or nilotinib after imatinib failure. Left ventricular systolic functions were evaluated using four-dimensional speckle tracking echocardiography derived global longitudinal (GLS), circumferential (GCS), radial (GRS), and area (GAS) strain indices. Mean ejection fraction, stroke volume, cardiac output and left ventricular mass index were similar between control and patient groups and within normal limits. GLS (− 16.7% vs − 20.8%, p
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