Functional tumour burden of peritoneal carcinomatosis derived from DWI could predict incomplete tumour debulking in adva
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ONCOLOGY
Functional tumour burden of peritoneal carcinomatosis derived from DWI could predict incomplete tumour debulking in advanced ovarian carcinoma Elaine Y. P. Lee 1 & He An 1 Hextan Y. S. Ngan 2
& Jose A. U. Perucho
1
& Keith W. H. Chiu
1
& Edward S. Hui
1
& Mandy M. Y. Chu
2
&
Received: 12 January 2020 / Revised: 13 March 2020 / Accepted: 9 April 2020 # European Society of Radiology 2020
Abstract Objectives To investigate the predictive value of peritoneal carcinomatosis (PC) quantification by DWI in determining incomplete tumour debulking in ovarian carcinoma (OC). Methods Prospective patients with suspected stage III–IV or recurrent OC were recruited for DWI before surgery. PC on DWI was segmented semi-automatically by k-means clustering, retaining voxels with intermediate apparent diffusion coefficient (ADC) to quantify PC burden. A scoring system, functional peritoneal cancer index (fPCI), was proposed based on the segmentation of tumour volume in 13 abdominopelvic regions with additional point given to involvement of critical sites. ADC of the largest PC was recorded. The surgical complexity and outcomes (complete vs. incomplete tumour debulking) were documented. fPCI was correlated with surgical PCI (sPCI), surgical complexity, and its ability to predict incomplete tumour debulking. Results Fifty-three patients with stage III–IVor recurrent OC were included with a mean age of 56.1 ± 11.8 years old. Complete tumour debulking was achieved in 38/53 patients (71.7%). Significant correlation was found between fPCI and sPCI (r > 0.757, p < 0.001). Patients with high-fPCI (fPCI ≥ 6) had a high surgical complexity score (p = 0.043) with 84.2% received radical or supra-radical surgery. The mean fPCI was significantly higher in patients with incomplete tumour debulking than in those with complete debulking (10.27 vs. 4.71, p < 0.001). fPCI/ADC combined with The International Federation of Gynecology and Obstetrics stage achieved 92.5% accuracy in predicting incomplete tumour debulking (AUC 0.947). Conclusions DWI-derived fPCI offered a semi-automated estimation of PC burden. fPCI/ADC could predict the likelihood of incomplete tumour debulking with high accuracy. Key Points • Functional peritoneal cancer index (fPCI) derived from DWI offered a semi-automated estimation of tumour burden in ovarian carcinoma. • fPCI was highly correlated with surgical PCI (sPCI). • fPCI/ADC could predict the likelihood of incomplete tumour debulking with high accuracy. Keywords Diffusion magnetic resonance imaging . Ovarian neoplasms . Neoplasm, residual . Peritoneal neoplasms
* Elaine Y. P. Lee [email protected] 1
Department of Diagnostic Radiology, Queen Mary Hospital, University of Hong Kong, Pok Fu Lam, Hong Kong
2
Department of Obstetrics and Gynaecology, Queen Mary Hospital, University of Hong Kong, Pok Fu Lam, Hong Kong
Abbreviations CA-125 Cancer antigen-125 CS Complexity score FIGO The International Federation of Gynecology and Obstetrics fPCI Functional peritoneal cancer index FTV Functional tumour volume I
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