Genetic Control of the Susceptibility to Bacterial Infection

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Editors A. Clarke, ParkvilleNictoria . R W. Compans, Birmingham/Alabama . M Cooper, Birmingham/Alabama

H. Eisen, Paris . W. Goebel, Wiirzburg . H. Koprowski, Philadelphia . F. Melchers, Basel . M. Oldstone, La Jolla/California . R Rott, GieBen . P.K Vogt, Los Angeles H. Wagner, U1m . I. Wilson, La Jolla/California

Genetic Control of the Susceptibility to Bacterial Infection Edited by David E. Briles

With 19 Figures

Springer-Verlag Berlin Heidelberg NewYork Tokyo

Professor Dr. DAVID E. BRILES, Ph.D. Cellular Immunobiology Unit of the Tumor Institute Department of Microbiology and Pediatrics, and Comprehensive Cancer Center University of Alabama at Birmingham Birmingham, Alabama 35294, USA

ISBN-I3: 978-3-540-16238-4

e-ISBN-I3: 978-3-642-70986-9

001: 10.1007/978-3-642-70986-9

This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically those of translation, reprinting, re-use of illustrations, broadcasting, reproduction by photocopying machine or similar means, and storage in data banks. Under § 54 of the German Copyright Law where copies are made for other than private use, a fee is payable to "Verwertungsgesellschaft Wort", Munich © by Springer-Verlag Berlin Heidelberg 1986 Softcover reprint of the hardcover Ist edition 1986

Library of Congress Catalog Card Number 15-12910 The use of registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. Product Liability: The publishers can give no guarantee for information about drug dosage and application thereof contained in this book. In every individual case the respective user must check its accuracy by consulting other pharmaceutical literature.

2123/3130-543210

Preface

This series of reviews focuses on recent developments in understanding bacterial pathogenesis that have been gained by studying the genetic control of the susceptibility to particular diseases. The topics of the reviews include a description of bacterial genes that effect virulence and a study of the genetic susceptibility of humans to group A streptococci and to leprosy. The most versatile model system for studies of disease susceptibility is the inbred mouse. Although seven of the chapters deal with the genetics of the resistance of mice to infection, all of them point out general principles and, wherever possible, parallels with appropriate human diseases. Genetic studies of the mechanisms of resistance and pathogenesis have an advantage over other approaches. By utilizing animals of appropriate genotypes, it is possible to study the in vivo consequences of variations in particular host defenses in intact animals. Some of the modern genetic approaches used in mouse genetics are also described. All of the chapters dealing with mouse genetics describe studies with recombinant inbred mice. A chapter has been included that describes approaches for the use o