GeodesicSlicer: a Slicer Toolbox for Targeting Brain Stimulation
- PDF / 2,286,085 Bytes
- 8 Pages / 595.276 x 790.866 pts Page_size
- 41 Downloads / 176 Views
ORIGINAL ARTICLE
GeodesicSlicer: a Slicer Toolbox for Targeting Brain Stimulation F. Briend 1
&
E. Leroux 1 & C. Nathou 1,2 & N. Delcroix 3 & S. Dollfus 1,2 & O. Etard 1,4
# Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract NonInvasive Brain Stimulation (NIBS) is a potential therapeutic tool with growing interest, but neuronavigation-guided software and tools available for the target determination are mostly either expensive or closed proprietary applications. To address these limitations, we propose GeodesicSlicer, a customizable, free, and open-source NIBS therapy research toolkit. GeodesicSlicer is implemented as an extension for the widely used 3D Slicer medical image visualization and analysis application platform. GeodesicSlicer uses cortical stimulation target from either functional or anatomical images to provide functionality specifically designed for NIBS therapy research. The provided algorithms are tested and they are accessible through a convenient graphical user interface. Modules have been created for NIBS target determination according to the position of the electrodes in the 10–20 system electroencephalogram and calculating correction factors to adjust the repetitive Transcranial Magnetic Stimulation (rTMS) dose for the treatment. Two illustrative examples are processing with the module. This new open-source software has been developed for NIBS therapy: GeodesicSlicer is an alternative for laboratories that do not have access to neuronavigation system. The triangulation-based MRI-guided method presented here provides a reproducible and inexpensive way to position the TMS coil that may be used without the use of a neuronavigation system. Keywords NIBS . rTMS . 3D slicer . EEG . Target determination . Correction factor
Introduction A key issue in the field of NonInvasive Brain Stimulation (NIBS) is to determine an accurate localization on the scalp to correctly target cortical areas knowing the great anatomical variability of the brain. Since personalized medicine for the treatment of psychosis allows for the consideration of substantial inter-individual variability, recent findings claim that brain stimulation can be guided in a personalized manner (Briend et al. in review; Kraus and Gharabaghi 2015; Lahti 2016; Sommer et al. 2018).
* F. Briend [email protected]; http://www.ists.cyceron.fr/ 1
Normandie Univ, UNICAEN, ISTS EA 7466, GIP CYCERON, F-14000 Caen, France
2
CHU de Caen, Service de Psychiatrie adulte, Centre Esquirol, 14000 Caen, France
3
Normandie Univ, UNICAEN, CNRS, CHU de Caen, UMS 3408, GIP Cyceron, 14000 Caen, France
4
Service d’Explorations Fonctionnelles du Système Nerveux, CHU de Caen, 14000 Caen, France
Most clinical applications of the NIBS are based on probabilistic targeting methods which do not account for individual anatomical variability (e.g. for major depressive episodes the so called “5-cm rule” (Herwig et al. 2001) or the International 10–20 electroencephalogram (EEG) (De Witte et al. 2018; Herwig et al. 2003) or derivative system
Data Loading...
