HBV infection may reduce the risk of metachronous liver metastasis in postoperative pathological stage 2 colorectal canc
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ORIGINAL ARTICLE
HBV infection may reduce the risk of metachronous liver metastasis in postoperative pathological stage 2 colorectal cancer Zhou Jiaming 1,2 & Huang Pinzhu 1,2 & Guo Xiaoyan 3 & Tan Shuyun 1,2 & Lin Rongwan 4 & Zhan Huanmiao 5 & Wu Xiaofeng 6 & Xiao Yuanlv 1,2 & Huang Mingzhe 1,2 & Yu Hongen 7 & Huang Meijin 1,2 & Wang Jianping 1,2 Accepted: 23 July 2020 # Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract Purpose To analyze whether HBV infection can reduce the risk of colorectal liver metastasis (CRLM) in stage 2 colorectal cancer (CRC). Methods The data of postoperative pathological stage 2 CRC patients treated at the Sixth Affiliated Hospital of Sun Yat-sen University between 2013 and 2015 were analyzed. The patients were divided into an infection group (group A) and a noninfection group (group B). The correlations between HBV infection and CRLM, 5-year liver disease-free survival, and 5-year overall survival were compared. Results A total of 884 patients who met the inclusion criteria were included in the study. Group A included 297 patients (33.60%), and 5 patients (1.68%) had CRLM. Group B included 587 patients (66.40%), and 31 patients (5.28%) had CRLM. The results of correlation analysis and logistic regression analysis showed that HBV infection (P = 0.013, HR = 0.29, 95% CI 0.11–0.77) was a protective factor for CRLM, while CEA > 5 ng/ml (P = 0.002, HR = 3.12, 95% CI 1.51–6.47) and hypertension (P = 0.010, HR = 3.50, 95% CI 1.34–9.09) were risk factors for CRLM. Group A had a significantly better 5-year liver diseasefree survival than group B (P = 0.011, HR = 0.31, 95% CI 0.16–0.63), but there was no significant difference in the 5-year overall survival (P = 0.433). Conclusion HBV infection may reduce the risk of metachronous liver metastasis in stage 2 colorectal cancer. Keywords Colorectal cancer . Liver metastasis . HBV infection
Introduction Colorectal cancer (CRC) has the third-highest incidence rate of malignant tumors in the world, with the fourth in men and the third in women [1]. Nearly 80,000 new cases occur annually in China, with a statistical incidence rate of 27.47/100,000 [2]. The liver is the most frequent metastatic site of colorectal
cancer. Malignant nodules in the liver from colorectal cancer metastasis are called CRLM. Synchronous liver metastasis (SYN-CRLM) was found in 15–25% of patients at the first diagnosis, while the proportion of metachronous liver metastasis (MET-CRLM) within 5 years after the first diagnosis was nearly 18–25% [3]. According to the previous literature, the incidence of CRLM was 1.2%, 13.6%, 27.8%, and 32.1% in
* Huang Meijin [email protected]
3
Department of Infectious Diseases, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China
* Wang Jianping [email protected]
4
Department of Clinical Laboratory, The Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China
5
Department of Pathology, The Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, C
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