Heart rate variability as possible marker of brain damage in neonates with hypoxic ischemic encephalopathy: a systematic
- PDF / 443,636 Bytes
- 11 Pages / 595.276 x 790.866 pts Page_size
- 30 Downloads / 172 Views
REVIEW
Heart rate variability as possible marker of brain damage in neonates with hypoxic ischemic encephalopathy: a systematic review Iliana Bersani 1 & Fiammetta Piersigilli 1 & Diego Gazzolo 2 & Francesca Campi 1 & Immacolata Savarese 1 & Andrea Dotta 1 & Pietro Paolo Tamborrino 3 & Cinzia Auriti 1 & Corrado Di Mambro 3 Received: 26 June 2020 / Revised: 18 October 2020 / Accepted: 18 November 2020 # Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract Heart rate variability (HRV) is currently considered the most valuable non-invasive test to investigate the autonomic nervous system function, based on the fact that fast fluctuations might specifically reflect changes of sympathetic and vagal activity. An association between abnormal values of HRV and brain impairment has been reported in the perinatal period, although data are still fragmentary. Considering such association, HRV has been suggested as a possible marker of brain damage also in case of hypoxic-ischemic encephalopathy following perinatal asphyxia. The aim of the present manuscript was to review systematically the current knowledge about the use of HRV as marker of cerebral injury in neonates suffering from hypoxic-ischemic encephalopathy. Findings reported in this paper were based on qualitative analysis of the reviewed data. Conclusion: A growing body of research supports the use of HRV as non-invasive, bedside tool for the monitoring of hypoxicischemic encephalopathy. The currently available data about the role of HRV as prognostic tool in case of hypoxic ischemic encephalopathy are promising but require further validation by future studies.
What is Known: • Heart rate variability (HRV) is a non-invasive monitoring technique to assess the autonomic nervous system activity. • A correlation between abnormal HRV and cerebral injury has been reported in the perinatal period, and HRV has been suggested as possible marker of brain damage in case of hypoxic-ischemic encephalopathy. What is New: • HRV might provide precocious information about the entity of brain injury in asphyxiated neonates and be of help to design early, specific, and personalized treatments according to severity. • Further investigations are required to confirm these preliminary data.
Communicated by Daniele De Luca * Iliana Bersani [email protected]
Pietro Paolo Tamborrino [email protected] Cinzia Auriti [email protected]
Fiammetta Piersigilli [email protected]
Corrado Di Mambro [email protected]
Diego Gazzolo [email protected] Francesca Campi [email protected] Immacolata Savarese [email protected] Andrea Dotta [email protected]
1
Department of Medical and Surgical Neonatology, Bambino Gesù Children’s Hospital, Rome, Italy
2
Neonatal Intensive Care Unit, G. d’Annunzio University, Chieti, Italy
3
Pediatric Cardiology and Cardiac Arrhythmia/Syncope Complex Unit, Department of Pediatric Cardiology and Cardiac Surgery, Bambino Gesù Children’s Hospital, Rome, Italy
Eur J Pediatr
Keywords Heart
Data Loading...
