High-Risk Cutaneous Squamous Cell Carcinoma A Practical Guide for Pa
This book is a cutting-edge resource that provides clinicians with the up-to-date practical knowledge required in order to manage SCC patients optimally. It summarizes newly available information relating to the definition of high-risk SCC, its pathophysi
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High-Risk Cutaneous Squamous Cell Carcinoma
Chrysalyne D. Schmults Editor
High-Risk Cutaneous Squamous Cell Carcinoma A Practical Guide for Patient Management
Editor Chrysalyne D. Schmults, MD, MSCE Director, Mohs & Dermatologic Surgery Center Brigham & Women’s Hospital Department of Dermatology Boston, MA, USA
ISBN 978-3-662-47080-0 ISBN 978-3-662-47081-7 (eBook) DOI 10.1007/978-3-662-47081-7 Library of Congress Control Number: 2015956335 © Springer-Verlag Berlin Heidelberg 2016 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper This Springer imprint is published by Springer Nature The registered company is Springer-Verlag GmbH Berlin Heidelberg
To my husband and daughters who have shown great patience with my distraction while editing this book.
Preface
My coauthors and I are happy to bring you this inaugural textbook on high-risk cutaneous squamous cell carcinoma. We feel it is timely in that many advances in defining this entity have occurred in recent years and we’re witnessing the beginning of the serious study of this historically understudied disease. If any subsequent editions of this text are released, they will almost certainly contain important advances in prognostic stratification, our understanding of the molecular and genetic underpinnings of aggressive tumor formation and progression, accurate disease staging, and even treatment. Although the study of high-risk cutaneous squamous cell carcinoma is in its infancy, it will not remain there for long. Many distinguished investigators, many of whom are authors of this book, are hard at work to bring new information to light that will ultimately benefit patients who suffer from this difficult disease. Meanwhile, we hope that you will find this a useful compendium of current knowledge. Boston, MA, USA
Chrysalyne D. Schmults, MD, MSCE
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Contents
Part I 1
2
Epidemiology and Outcomes of Cutaneous Squamous Cell Carcinoma...................................................
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