High-Sensitive c-Reactive Protein Levels in Euthymic Bipolar Patients: Case-Control Study
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High-Sensitive c-Reactive Protein Levels in Euthymic Bipolar Patients: Case-Control Study Ghada Hamdi 1,2 & Hanen Ben Ammar 1,2 & Emira Khelifa 1 & Arij Ben Chaaben 3 & Sabria Khouadja 3 & Fayza Ayari 3 & Ons Mihoub 3 & Ryad Tamouza 4,5 & Fethi Guémira 3 & Zouhaier Elhechmi 1 Accepted: 18 October 2020/ # Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract
Bipolar disorder is a chronic, disabling disease that is characterized by the recurrence of thymic episodes. The role of the immune-inflammatory system in the etiopathogenesis of this affection arouses the interest of research. The aim of this work was to determine the plasma levels of the high sensitivity C reactive protein (hs-CRP) in patients with bipolar disorder in remission phase by comparing them to a control group. A case-control cross-sectional study was conducted from 56 subjects with bipolar disorder in clinical remission, and 56 volunteers and healthy control subjects. Mean plasma hs-CRP was significantly higher in patients with bipolar disorder than control subjects. In bipolar patients, a hs-CRP elevation was significantly associated with the disease severity item mean score. Through this study, bipolar disorder appears to be associated with a state of chronic inflammation. This should lead to randomized controlled trials evaluating the value of anti-inflammatory drugs in the management of bipolar disorder. Keywords Bipolar disorder . Inflammation . C-reactive protein . Inflammatory marker
Ghada Hamdi and Hanen Ben Ammar contributed equally to this work.
* Ghada Hamdi [email protected] * Hanen Ben Ammar [email protected]
1
Faculty of Medicine of Tunis, El Manar University, Tunis, Tunisia
2
Psychiatry Department “F”, Razi Hospital, 2010 Manouba, Tunisia
3
Clinical Biology Department, Salah Azaiz Institute, Tunis, Tunisia
4
Faculté of Medicine of Monastir, Monastir, Tunisia
5
Department of psychiatry, university hospital Mondor, Paris, France
Psychiatric Quarterly
Introduction Bipolar disorder (BPD) is a nosographic group of chronic psychiatric diseases, affecting about 1% of the general population [1]. They are characterized by a succession of thymic episodes ranging from mania to severe depression, interspersed with periods of emotional stability [1]. BPD resounds early on the social, professional and emotional development of patients; it is one of the ten most disabling diseases, in terms of years of life lost to premature death and / or lived with a major disability [16]. The Com grip of the pathophysiological mechanisms of BPD, to an early diagnosis and better care, seems a psychiatric research priority. The literature expands on new studies suggesting the existence of immunological and inflammatory dysfunction during the symptomatic phases of BPD [9]. This modern concept has emerged thanks to the existence of autoimmune comorbidities and to the detection of immunological abnormalities threw the evolution of BPD and summed up with proinflammatory profiles [4]. Rosenblat et al. [20] an existing re
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