High Throughput Screening Methods and Protocols
This third edition volume expands on the previous editions both by presenting more detailed protocols for the techniques described in the first and second editions of High Throughput Screening: Methods and Protocols and by covering important new procedure
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William P. Janzen Editor
High Throughput Screening Methods and Protocols Third Edition
METHODS
IN
MOLECULAR BIOLOGY
Series Editor John M. Walker School of Life and Medical Sciences University of Hertfordshire Hatfield Hertfordshire, UK
For further volumes: http://www.springer.com/series/7651
High Throughput Screening Methods and Protocols Third Edition
Edited by
William P. Janzen Epizyme, Inc. Cambridge, MA, USA
Editor William P. Janzen Epizyme, Inc. Cambridge, MA, USA
ISSN 1064-3745 ISSN 1940-6029 (electronic) Methods in Molecular Biology ISBN 978-1-4939-3671-7 ISBN 978-1-4939-3673-1 (eBook) DOI 10.1007/978-1-4939-3673-1 Library of Congress Control Number: 2016941460 © Springer Science+Business Media New York 2016 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper This Humana Press imprint is published by Springer Nature The registered company is Springer Science+Business Media LLC New York
Preface Everything changes and nothing stands still—Heraclitus of Ephesus
This quote from Heraclitus was written almost 2500 years ago but could not fit the modern world more clearly. It has definitely proven true of the field of High Throughput Screening (HTS). When I began to work in HTS in 1989 it was virtually unheard of outside of a few industrial research laboratories. As an illustration, there are nine citations in PubMed from that year that contain “HTS” or “High Throughput Screening” in the title or key words. In 2013 there were over 2000. HTS has become integrated with large segments of research and across many fields. It has evolved from a highly specialized and secretive activity to a function that is made available to researchers through academic core labs. But, “the more things change the more they stay the same” (Jean-Baptiste Alphonse Karr). This quote is also true of HTS. The basic processes underlying HTS have not changed in the last 25 years. Test a large number of potential effectors of a biological system as rapidly as possibl
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