Higher Incidence of Protein-Losing Enteropathy in Patients with Single Systemic Right Ventricle
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ORIGINAL ARTICLE
Higher Incidence of Protein‑Losing Enteropathy in Patients with Single Systemic Right Ventricle Alyssa M. Bernardi1 · Sylvestor Moses2 · Brent J. Barber3 · Marlys H. Witte4 · Michael D. Seckeler3 Received: 21 April 2020 / Accepted: 16 September 2020 © Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract Patients with single ventricle congenital heart disease are at risk of unpredictable protein-losing enteropathy (PLE) after surgical palliation. Based on prior reports of physiologic differences for patients with single morphologic right versus left ventricles, we hypothesized that those with right ventricular morphology would have a higher incidence of PLE. We performed a retrospective review of > 15 million pediatric hospitalizations from the Healthcare Cost and Utilization Project KID 2000–2012 databases for admissions 5–21 years old with ICD-9 codes for hypoplastic left heart syndrome (HLHS) and tricuspid atresia (TA) with and without PLE. Incidence of PLE was compared between those with HLHS and TA. In addition, outcomes and costs were compared between admissions with and without PLE and between HLHS and TA. Of 1623 HLHS admissions, 289 (17.8%) had PLE, and of 926 TA admissions, 58 (5.9%) had PLE (p
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