Hotspot Analysis of Traditional Drugs in Diabetes Treatment Literature
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hinese Journal of Integrative Medicine
Available online at link.springer.com/journal/11655 Journal homepage: www.cjim.cn/zxyjhen/zxyjhen/ch/index.aspx E-mail: [email protected]
Literature Research
Hotspot Analysis of Traditional Drugs in Diabetes Treatment Literature SHEN Hui1, ZHU Wei-kai1, LU Zhi2, and ZHOU Hai-cheng3 Objective:: To summarize current hotspots and predict the potential trends in traditional drugs of ABSTRACT Objective Methods:: Publications on the application of traditional drugs in diabetes diabetes treatment for further research. Methods treatment were searched from PubMed without language limits. Highly frequent MeSH terms were identified through Bibliographic Item Co-Occurrence Matrix Builder (BICOMB). Biclustering analysis results were visualized Results:: Totally 2,386 relevant utilizing the gCLUTO software. Finally, a strategic diagram was generated. Results publications were obtained from PubMed on November 9th, 2018, and 69 highly frequent MeSH terms were identified. Biclustering analysis revealed that these highly frequent MeSH terms were classified into 7 clusters. After calculating the density and centrality of each cluster, strategy diagram was presented. Cluster 0 "Chinese medicine monomers such as antioxidant and hypoglycemic effects" was considered as the most potential research hotspot. Conclusions: In this study, we found 7 topics related to the application of traditional drugs in diabetes treatment. The molecular mechanisms of Chinese medicine monomers in diabetes could become a potential hotspot with high centricity and low density. KEYWORDS hotspot, traditional drug, diabetes, bibliometrics, MeSH term, Chinese medicine
Diabetes is a group of long-term, chronic, metabolic diseases characterized by persistent high blood glucose levels. Diabetes that are not effectively controlled for a long time usually causes various serious complications such as acute exacerbation of lethal diabetes pyruvate and hyperosmolar coma,(1) in addition to severe chronic and organic lesions, such as cardiovascular disease,(2) stroke,(3) chronic kidney disease(4) and retinopathy,(5) etc. Statistics showed that in 2016, global diabetes patients reached 442 million. Furthermore, the number of patients with diabetes had a rapid increase in low- and middle-income countries.(6) Chinese medicine (CM) for the treatment of diabetes has been in China for more than 2,000 years.(7) Study has shown that traditional drugs for the treatment of diabetes often have low toxicity and few side effects.(8) Because of the complex composition of traditional medicines, they tend to have a wider range of therapeutic effects, more targets, and thus better results.(9,10) In recent years, in the relevant researches on the development of novel drugs for diabetes, more and more people have focused on traditional medicines. So far, researches on the application of traditional medicines to treat diabetes have focused on the efficacy and side effects of CM,(11-13) comparison
with the efficacy of conventional drugs, (14-16)
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