Hypoperfusion Intensity Ratio Predicts Malignant Edema and Functional Outcome in Large-Vessel Occlusive Stroke with Poor

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ORIGINAL WORK

Hypoperfusion Intensity Ratio Predicts Malignant Edema and Functional Outcome in Large‑Vessel Occlusive Stroke with Poor Revascularization Nick M. Murray1,3*  , Collin J. Culbertson1, Dylan N. Wolman2, Michael Mlynash1 and Maarten G. Lansberg1 © 2020 Springer Science+Business Media, LLC, part of Springer Nature and Neurocritical Care Society

Abstract  Background and Objective:  Malignant cerebral edema (MCE) is a well-known complication in patients with acute ischemic stroke with core infarcts ≥ 80 mL caused by large-vessel occlusions. MCE can also develop in patients with smaller infarcts with moderate -to-large volume of tissue at risk who do not achieve successful revascularization with endovascular thrombectomy (ET). Features that predict the development of MCE in this population are not welldescribed. We aim to identify predictors of MCE and 90-day functional outcome in stroke patients with an anterior circulation large vessel occlusion (LVO) and a