Induction Chemotherapy Systemic and Locoregional

This book presents the full range of management techniques and practices used in induction chemotherapy – both systemic and locoregional - by experienced international groups within one accessible volume. It provides the latest information on the pioneeri

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Induction Chemotherapy

Karl Reinhard Aigner Frederick O. Stephens Editors

Induction Chemotherapy Systemic and Locoregional Second Edition

Editors Karl Reinhard Aigner Department of Surgical Oncology Medias Klinikum GmbH & Co KG Burghausen Germany

Frederick O. Stephens Royal Prince Alfred Sydney Hospitals Mosman New South Wales Australia

ISBN 978-3-319-28771-3 ISBN 978-3-319-28773-7 DOI 10.1007/978-3-319-28773-7

(eBook)

Library of Congress Control Number: 2016936670 © Springer-Verlag Berlin Heidelberg 2016 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper This Springer imprint is published by Springer Nature The registered company is Springer International Publishing AG Switzerland

Contents

1 Introduction: Overview, History, Terminology and Early Clinical Experience . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 Frederick O. Stephens 2 The Principle of Dose Response in Antineoplastic Drug Delivery . . . . 25 Maurie Markman 3 Drug Removal Systems and Induction Chemotherapy . . . . . . . . . . . . . 31 James H. Muchmore 4 Cryotherapy. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 45 Miriam R. Habib and David L. Morris 5 Local and Regional Hyperthermia . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 53 Miriam R. Habib and David L. Morris 6 The Role of Hypoxia and Hyperthermia in Chemotherapy . . . . . . . . . 61 Giammaria Fiorentini, Maurizio Cantore, Francesco Montagnani, Andrea Mambrini, Michelina D’Alessandro, and Stefano Guadagni 7 Induction Chemotherapy in Head and Neck Cancers . . . . . . . . . . . . . . 73 Adorján F. Kovács 8 Isolated Thoracic Perfusion with Carotid Artery Infusion for Advanced and Chemoresistant Tumors of the Parotid Gland and Tonsils . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 123 Karl Reinhard Aigner, Emir Selak, and Rita Schlaf 9 Induction Chemotherapy for Breast Cancer . . . . . . . . . . . . . . . .