Short-term outcomes of induction chemotherapy with docetaxel, cisplatin, and fluorouracil (TPF) in locally advanced naso
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SHORT REPORT
Short-term outcomes of induction chemotherapy with docetaxel, cisplatin, and fluorouracil (TPF) in locally advanced nasopharyngeal carcinoma Shigemasa Takamizawa 1 & Yoshitaka Honma 1 & Naoya Murakami 2 & Taisuke Mori 3 & Hiroki Oka 1 & Shun Yamamoto 1 & Tairo Kashihara 2 & Kimiteru Ito 4 & Yuko Kubo 4 & Atsuo Ikeda 5 & Fumihiko Matsumoto 5 & Go Omura 5 & Kenya Kobayashi 5 & Jun Itami 2 & Ken Kato 1 & Seiichi Yoshimoto 5 Received: 14 July 2020 / Accepted: 4 September 2020 # Springer Science+Business Media, LLC, part of Springer Nature 2020
Summary There is an unmet need for improving survival outcomes of locally advanced nasopharyngeal carcinoma, for example, T4/ N3 stage disease. To this end, we administered induction chemotherapy (IC) with TPF (docetaxel, cisplatin, and fluorouracil) because this stage of disease is associated with a high risk of recurrence and is difficult to control with standard treatments, such as chemoradiotherapy (CRT) alone or CRT followed by adjuvant chemotherapy. The aim of this retrospective single-center study was to clarify the short-term outcomes of locally far-advanced nasopharyngeal carcinoma patients treated with IC-TPF, followed by CRT with cisplatin. Data from 11 patients were extracted from our database, indicating that the overall response rate to ICTPF, clinical complete response rate after CRT, 1-year progression-free survival, and 1-year overall survival were 73%, 91%, 68%, and 89%, respectively. Hematological toxicity was the most common adverse event reported during IC-TPF with 64% of patients suffering grade 3 or 4 neutropenia, 55% grade 3 or 4 leucopenia and 9% febrile neutropenia. Despite the small number of patients, these data are important because there is a limited number of studies investigating IC-TPF followed by CRT in Japanese patients. This pilot study provides some indication of the short-term effectiveness and toxicity of this therapeutic approach, which may be superior to standard treatments. Long-term follow-up is warranted to assess the effectiveness of IC-TPF in terms of clinical outcome and late-phase toxicity. Keywords Nasopharyngeal carcinoma . Induction chemotherapy . Chemoradiotherapy . Docetaxel . Cisplatin . Fluorouracil
Background
* Yoshitaka Honma [email protected] 1
Head and Neck Medical Oncology Division, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-Ku, Tokyo 104-0045, Japan
2
Department of Radiation Oncology, National Cancer Center Hospital, Tokyo, Japan
3
Department of Diagnostic Pathology, National Cancer Center Hospital, Tokyo, Japan
4
Department of Diagnostic Radiology, National Cancer Center Hospital, Tokyo, Japan
5
Department of Head and Neck Surgery, National Cancer Center Hospital, Tokyo, Japan
Because the surgical approach to localized nasopharyngeal carcinoma (NPC) is anatomically difficult and highly invasive, radiation therapy (RT) has been the standard treatment thus far. However, some previous reports indicated that patients with locally advanced nasopharyngeal carcinoma (LANPC) treated with ch
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