Inflammatory responses to acute exercise during pulmonary rehabilitation in patients with COPD
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ORIGINAL ARTICLE
Inflammatory responses to acute exercise during pulmonary rehabilitation in patients with COPD Alex R. Jenkins1 · Neil S. Holden2 · Arwel W. Jones3 Received: 16 March 2020 / Accepted: 30 July 2020 © The Author(s) 2020
Abstract Objective Pulmonary rehabilitation is a cornerstone treatment in the management of chronic obstructive pulmonary disease (COPD). Acute bouts of exercise can lead to short bursts of inflammation in healthy individuals. However, it is unclear how COPD patients respond to acute bouts of exercise. This study assessed inflammatory responses to exercise in COPD patients at the start (phase 1) and end (phase 2) of pulmonary rehabilitation. Methods Blood samples were collected before and after an acute exercise bout at the start (phase 1, n = 40) and end (phase 2, n = 27) of pulmonary rehabilitation. The primary outcome was change in fibrinogen concentrations. Secondary outcomes were changes in CRP concentrations, total/differential leukocyte counts, markers of neutrophil activation (CD11b, CD62L and CD66b), and neutrophil subsets (mature, suppressive, immature, progenitor). Results Acute exercise (phase 1) did not induce significant changes in fibrinogen (p = 0.242) or CRP (p = 0.476). Total leukocyte count [mean difference (MD), 0.5 ± 1.1 ( 109 L−1); p = 0.004], neutrophil count [MD, 0.4 ± 0.8 ( 109 L−1); p
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