Inflammatory Variant of Atypical Lipomatous Tumor/Well-Differentiated Liposarcoma of the Buccal Mucosa: An Overview and
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CASE REPORTS
Inflammatory Variant of Atypical Lipomatous Tumor/ Well‑Differentiated Liposarcoma of the Buccal Mucosa: An Overview and Case Report with a 10‑Year Follow‑Up José Alcides Almeida de Arruda1 · Diego Antônio Costa Arantes2 · Lauren Frenzel Schuch1 · Lucas Guimarães Abreu3 · Bruno Augusto Benevenuto de Andrade4 · Mário José Romañach4 · Ricardo Alves Mesquita1 · Satiro Watanabe5 · José Carlos de Oliveira6 · Elismauro Francisco Mendonça2 Received: 28 August 2020 / Accepted: 16 October 2020 © Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract Liposarcomas of the oral cavity are rare. Those originating in the buccal mucosa cause challenging diagnostic and therapeutic issues since less than 40 cases of liposarcomas of the buccal mucosa and cheek have been reported in the worldwide literature. Herein, we present a case of atypical lipomatous tumor/well-differentiated liposarcoma affecting a 45-year-old female patient. Ultrasonography and magnetic resonance imaging confirmed a well-defined mass located in the right buccal mucosa, extending to the submucosal layers of the cheek. Histopathologically, a well-differentiated fatty neoplasm with presence of prominent stromal inflammatory cells was observed. Multifocally scattered bizarre hyperchromatic stromal cells, some of which multinucleated, were also observed. An immunohistochemical panel comprising vimentin, S-100, CD10, CD34, CD20, CD3, CD68, CD138, MDM2, Ki-67, and P53 was employed to better characterize the lesion. A local recurrence event occurred during a 10-year follow-up period. Surgical resection was performed during both episodes. We also provided an overview of demographic and clinicopathological characteristics, immunohistochemical features, imaging findings, and the differential diagnosis of liposarcoma of the oral cavity. Knowledge of the etiopathological and clinical aspects of this rare neoplasm is fundamental in order to rule out other conditions, including lipomatous lesions that affect the buccal mucosa. Keywords Atypical lipomatous tumor · Liposarcoma · Mouth mucosa · Oral cancer · Recurrence · Well differentiated liposarcoma * José Alcides Almeida de Arruda [email protected]; [email protected] 1
Department of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais, Av. Pres. Antônio Carlos, 6627, room 3202 D. Pampulha, Belo Horizonte, MG CEP: 31.270‑901, Brazil
2
Department of Stomatology (Oral Pathology), School of Dentistry, Universidade Federal de Goiás, Goiânia, GO, Brazil
3
Department of Child’s and Adolescent’s Oral Health, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil
4
Department of Oral Diagnosis and Pathology, School of Dentistry, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil
5
Department of Oral Surgery, School of Dentistry, Universidade de Anápolis, Anápolis, GO, Brazil
6
Division of Head and Neck Surgery, Hospital de Cancer Araújo Jorge, Goiânia, GO, Brazil
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