Influenza A virus vaccine-H1N1
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Influenza A virus vaccine-H1N1 Gianotti-Crosti syndrome in a child: case report A 9-year-old boy developed Gianotti-Crosti syndrome after inoculation with influenza A virus vaccine-H1N1. A week after receiving intranasal influenza A virus vaccineH1N1 [dosage not stated], the boy presented with a pruritic rash on his hands, knees, elbows, thighs, buttocks and ankles for 3 days. Ten days before presentation, he had an infection on his right leg and had been treated with topical retapamulin. Physical examination revealed multiple papules and papulovesicular lesions on the affected skin; these lesions were symmetrically dispersed, discrete and flesh coloured. They were flat-topped on the elbows, knees and ankles. Various viral culture tests returned negative results. A biopsy sample from his left elbow revealed orthokeratosis and focal parakeratosis over a gently papillated epidermis along with spongiosis and scattered collections of Langerhans cells. In the underlying superficial papillary dermis, there was a slight perivascular lymphohistiocytic inflammatory cell infiltrate with rare eosinophils observed. Papillary dermal oedema was also detected. The boy was treated with oral antihistamines and midpotent steroid creams. His symptoms had improved at 1-week follow-up [outcome not clearly stated]. Author comment: "In our patient, the close temporal relationship between eruption and H1N1 vaccination supports a causal association." Kroeskop A, et al. Gianotti-Crosti syndrome after H1N1-influenza vaccine. Pediatric Dermatology 28: 595-596, No. 5, Sep-Oct 2011. Available from: URL: 803062534 http://dx.doi.org/10.1111/j.1525-1470.2011.01402.x - USA
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Reactions 19 Nov 2011 No. 1378
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