Initiation of antidepressant use among refugee and Swedish-born youth after diagnosis of a common mental disorder: findi
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ORIGINAL PAPER
Initiation of antidepressant use among refugee and Swedish‑born youth after diagnosis of a common mental disorder: findings from the REMAIN study Heidi Taipale1,2 · Thomas Niederkrotenthaler1,3 · Magnus Helgesson1 · Marit Sijbrandij4 · Lisa Berg5 · Antti Tanskanen1,2 · Ellenor Mittendorfer‑Rutz1 Received: 27 April 2020 / Accepted: 1 September 2020 © The Author(s) 2020
Abstract Purpose The objective of this study was to compare the initiation and type of antidepressant use between refugees and matched Swedish-born youth after a diagnosis of a common mental disorder (CMD) and assess sociodemographic and clinical factors associated with the initiation. Methods The study cohort included youth aged 16–25 years, with an incident diagnosis of CMD based on specialized health care registers in Sweden 2006–2016, without prior antidepressant use during 1 year. One Swedish-born person was matched for each identified refugee youth (N = 3936 in both groups). Initiation of antidepressant use and factors associated with the initiation, were investigated with logistic regression yielding Odds ratios, OR, and 95% Confidence Intervals, CI. Results Refugees were less likely to initiate antidepressant use compared with Swedish-born (40.5% vs. 59.6%, adjusted OR 0.43, 95% CI 0.39–0.48). Selective serotonin reuptake inhibitors (SSRIs) were less frequently initiated for refugees than Swedish-born (71.2% vs. 81.3% of initiations, p 10 years) and country of birth (Former Yugoslavia, Somalia, other Africa (other than Somalia), Iraq, Iran, Syria, Afghanistan, other Asia (other than previously mentioned), Chile/other South America, and other/unknown. Other medication use was assessed during 180 days before the CMD diagnoses, including use of anxiolytics (ATC-code N05B), hypnotics (N05C), opioids (N02A) and antipsychotics (N05A excl. N05AN01). For initiated antidepressants, we calculated the dispensing lag (for those who initiated the use) as time lapse between prescription date and dispensing date of the initiated antidepressants, and categorized as
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