Interaction of plant ingredients contained in Chatuphalathika herbal remedy based on chemical analysis aspect: four-comp
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RESEARCH ARTICLE
Interaction of plant ingredients contained in Chatuphalathika herbal remedy based on chemical analysis aspect: four‑component simplex lattice design Chaowalit Monton1 · Jirapornchai Suksaeree2 Received: 9 March 2020 / Accepted: 4 September 2020 © Institute of Korean Medicine, Kyung Hee University 2020
Abstract This work sought to apply the four-component simplex lattice experimental design to determine the chemical interaction between Terminalia chebula Retz. var. chebula, Terminalia arjuna Wight and Arn., Terminalia bellirica (Gaertn.) Roxb., and Phyllanthus emblica L., which are found in the traditional Chatuphalathika remedy. The four phenolic compounds, gallic acid, corilagin, chebulagic acid, and chebulinic acid, were quantified using validated high-performance liquid chromatography. A response surface analysis was also conducted to describe the level of interaction among the four plant ingredients. The results showed that a low content of P. emblica in the herbal remedy exhibited a positive effect on the extraction yield and the phenolic compounds content, except gallic acid. According to the combination index value, the low content of P. emblica in the herbal remedy revealed a positive effect on the interaction of extraction yield and the phenolic compounds content. The maximum interaction was found at an equal weight ratio of T. chebula, T. arjuna, and T. bellirica, with no P. emblica. The formula which boasts the equal weight ratio of three Terminalia plants exhibited a 167% increase in phenolic compounds as compared with the effects of any of the plants individually. Data from this work could be used to describe the synergy of plant ingredients contained in the Chatuphalathika remedy based on the chemical analysis aspect. Keywords Chatuphalathika · Phenolic compound · Simplex lattice design · Chemical interaction
Introduction Thai traditional medicine is a procedure of indigenous medical practice that has been used since ancient times in Thailand. Thai traditional medicine is also used for the treatment of many diseases as well as for health promotion. Thai traditional medicine usually uses herbal formula rather than the single-herb. The main purpose of the drug combination is to obtain synergy in therapy. It does not only improve the efficacy of the treatment; it may decrease toxicity, delay or decrease drug resistance, and targeting multiple targets (Chou 2018). Chatuphalathika is one of the herbal remedies * Chaowalit Monton [email protected] 1
Drug and Herbal Product Research and Development Center, College of Pharmacy, Rangsit University, Pathum Thani 12000, Thailand
Department of Pharmaceutical Chemistry, College of Pharmacy, Rangsit University, Pathum Thani 12000, Thailand
2
used in Thai traditional medicine. It composes of an equal ratio of the four components—dried fruits of Terminalia chebula Retz. var. chebula, Terminalia arjuna Wight and Arn., Terminalia bellirica (Gaertn.) Roxb., and Phyllanthus emblica L. It is used as an antipyretic, laxative, and health
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