Intestinal Microecology: An Important Target for Chinese Medicine Treatment of Non-alcoholic Fatty Liver Disease
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hinese Journal of Integrative Medicine
Available online at link.springer.com/journal/11655 Journal homepage: www.cjim.cn/zxyjhen/zxyjhen/ch/index.aspx E-mail: [email protected]
Feature Article
Intestinal Microecology: An Important Target for Chinese Medicine Treatment of Non-alcoholic Fatty Liver Disease LI Hong-shan1,2,3 and HU Yi-yang1
Prof. HU Yi-yang
ABSTRACT Non-alcoholic fatty liver disease (NAFLD) has become one of the most common chronic liver diseases worldwide, causing serious economic and medical burdens. Currently, Chinese medicine (CM) has become an important means in treating NAFLD in China. Intestinal microecology (IM) is an important part of the internal environment in the human body and is involved in the occurrence and development of NAFLD. In this paper, the authors systematically discuss the significance of IM in the pathogenesis of NAFLD and the current status of research on the CM treatment of NAFLD via IM regulation. In combination with our own research practice, we propose that IM is an important target for the treatment of NAFLD with CM and formulate plans for future research to target limitations existing in current studies. KEYWORDS intestinal microecology, non-alcoholic fatty liver disease, Chinese medicine
Non-alcoholic fatty liver disease (NAFLD) is a common chronic liver disease. One of its subtypes, non-alcoholic steatohepatitis (NASH), can progress to liver cirrhosis and hepatocellular carcinoma (HCC) and may become the most common cause of liver transplantation. (1) NAFLD has become the most common chronic liver disease in China and Western developed countries and has brought serious economic and medical burdens. (2,3) Active prevention and treatment of NAFLD is of great significance. However, currently, there is no ideal drug for the treatment of NAFLD. Chinese medicine (CM) has become a common method for the treatment of NAFLD in China, and its effectiveness, specificities and advantages are gradually being confirmed.(4) However, the specific mechanisms still require further exploration.
immune cells to regulate intestinal barrier function and inflammation and indirectly affect the occurrence and development of NAFLD. In addition, these metabolites can also pass through the intestinal barrier, enter the circulatory system, and bind to the farnesoid X receptor (FXR) and pregnane X receptor (PXR) in hepatocytes to mediate the occurrence of NAFLD.(7)
Intestinal microecology (IM) is an important part of the internal environment in the human body. It is composed of intestinal microbiota, intestinal epithelial cells and the immune system, forming the intestinal mucosal barrier and playing an important role in energy metabolism.(5) IM disturbance plays a key role in the pathogenesis of NAFLD and NAFLDrelated HCC.(6) Researchers found that gut microbiota metabolites, such as bile acids and short-chain fatty acids, can interact with intestinal epithelial cells and
©The Chinese Journal of Integrated Traditional and Western Medicine Press and Springer-Verlag GmbH Germany, part
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